Cargando…

Trehalose Enhances Long-term Recovery in 18-month-old Mice by Increasing Autophagy after Traumatic Brain Injury

Mostrar otras versiones (1)

Older patients with traumatic brain injury (TBI) have higher mortality and poorer long-term outlook compared to younger individuals. This may contribute to the assumption that aggressive management of geriatric TBI is futile. The present study examined the long-term recovery potential and underlying...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ritzel, Rodney, Li, Yun, Carter, Jordan, Khan, Niaz, He, Junyun, Allen, Samantha, Faden, Alan, Wu, Junfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969459/ http://dx.doi.org/10.1093/geroni/igab046.3543

Ejemplares similares

Trehalose Enhances Long-term Recovery in 18-month-old Mice by Increasing Autophagy after Traumatic Brain Injury
por: Ritzel, Rodney, et al.
Publicado: (2021)

Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
por: Ritzel, Rodney M., et al.
Publicado: (2022)

Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2019)

Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain
por: Li, Yun, et al.
Publicado: (2023)

Dementia, Depression, and Associated Brain Inflammatory Mechanisms after Spinal Cord Injury
por: Li, Yun, et al.
Publicado: (2020)

Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2020)

Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injury
por: Lei, Zhuofan, et al.
Publicado: (2023)

Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice
por: Li, Yun, et al.
Publicado: (2020)

Functions and Mechanisms of the Voltage-Gated Proton Channel Hv1 in Brain and Spinal Cord Injury
por: He, Junyun, et al.
Publicado: (2021)

The brain-bone marrow axis and its implications for chronic traumatic brain injury
por: Ritzel, Rodney M., et al.
Publicado: (2023)

Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice
por: Li, Yun, et al.
Publicado: (2022)

Functional phenotyping of microglia highlights the dark relationship between chronic traumatic brain injury and normal age-related pathology
por: Ritzel, Rodney M., et al.
Publicado: (2022)

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma
por: Lipinski, Marta M., et al.
Publicado: (2015)

Interaction of high-fat diet and brain trauma alters adipose tissue macrophages and brain microglia associated with exacerbated cognitive dysfunction
por: Henry, Rebecca J., et al.
Publicado: (2023)

Modified Whipple on an 18-month-old with traumatic pancreatic transection and duodenal rupture()()
por: Hyser, Elise, et al.
Publicado: (2019)

Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration
por: Ritzel, Rodney M., et al.
Publicado: (2023)

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits
por: Hanscom, Marie, et al.
Publicado: (2021)

Trehalose Accumulation Triggers Autophagy during Plant Desiccation
por: Williams, Brett, et al.
Publicado: (2015)

Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction
por: Lee, He-Jin, et al.
Publicado: (2018)

SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy
por: Mayer, Allyson L., et al.
Publicado: (2016)

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers
por: Colombo, Eleonora, et al.
Publicado: (2019)

Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study
por: Cunha, Anthony, et al.
Publicado: (2022)

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury
por: Sarkar, Chinmoy, et al.
Publicado: (2015)

Trehalose improves traumatic brain injury-induced cognitive impairment
por: Portbury, Stuart D., et al.
Publicado: (2017)

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
por: Hegdekar, Nivedita, et al.
Publicado: (2023)

Trehalose Augments Neuron Survival and Improves Recovery from Spinal Cord Injury via mTOR-Independent Activation of Autophagy
por: Zhou, Kailiang, et al.
Publicado: (2021)

Variable Effects of Autophagy Induction by Trehalose on Herpesviruses Depending on Conditions of Infection
por: Meier, Jeffery L., et al.
Publicado: (2017)

Old Maids: Aging and Its Impact on Microglia Function
por: Koellhoffer, Edward C., et al.
Publicado: (2017)

A Novel Trehalose Synthase for the Production of Trehalose and Trehalulose
por: Agarwal, Neera, et al.
Publicado: (2021)

Abrin Poisoning in an 18-Month-Old Child
por: Alhamdani, Mazin, et al.
Publicado: (2015)

Survived traumatic hemipelvectomy with salvage of the limb in a 14 months old toddler
por: Jansen, Hendrik, et al.
Publicado: (2019)

Trehalose May Decrease the Transmission of Zika Virus to the Fetus by Activating Degradative Autophagy
por: Yuan, Shu, et al.
Publicado: (2017)

The autophagy inducer trehalose stimulates macropinocytosis in NF1-deficient glioblastoma cells
por: Del Bello, Barbara, et al.
Publicado: (2022)

Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass
por: Sun, Guangchao, et al.
Publicado: (2022)

Temporomandibular Joint Dislocation in an 18-month-old Child
por: Painatt, Jaeson Mohanan, et al.
Publicado: (2017)

Rhabdomyosarcoma of the genital tract in an 18-month-old girl
por: ALSaleh, Nourah, et al.
Publicado: (2017)

An 18‐month‐old with white matter calcifications and seizures
por: Fiock, Kimberly L., et al.
Publicado: (2022)

Can 18-Month-Olds Revise Attributed Beliefs?
por: Király, Ildikó, et al.
Publicado: (2023)

A Novel Member of the Trehalose Transporter Family Functions as an H(+)-Dependent Trehalose Transporter in the Reabsorption of Trehalose in Malpighian Tubules
por: Kikuta, Shingo, et al.
Publicado: (2012)

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury
por: Kumar, Alok, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_5phealavbt70nuchrsmtrihpa0