Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection

BACKGROUND: Previously, we evaluated the intracellular mycobactericidal activity of the minor groove binder, S-MGB-364 against the clinical Mycobacterium tuberculosis (Mtb) strain HN878 in macrophages. OBJECTIVES: To assess the mycobactericidal activity of S-MGB-364 in Mtb-infected mice. Further, we...

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Detalles Bibliográficos
Autores principales: Kieswetter, Nathan S., Ozturk, Mumin, Hlaka, Lerato, Chia, Julius Ebua, Nichol, Ryan J. O., Cross, Jasmine M., McGee, Leah M. C., Tyson-Hirst, Izaak, Beveridge, Rebecca, Brombacher, Frank, Carter, Katharine C., Suckling, Colin J., Scott, Fraser J., Guler, Reto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969509/
https://www.ncbi.nlm.nih.gov/pubmed/35084027
http://dx.doi.org/10.1093/jac/dkac001

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