Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses

Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleuk...

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Autores principales: Martynova, Ekaterina, Rizvanov, Albert, Urbanowicz, Richard A., Khaiboullina, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969514/
https://www.ncbi.nlm.nih.gov/pubmed/35369454
http://dx.doi.org/10.3389/fmicb.2022.851835
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author Martynova, Ekaterina
Rizvanov, Albert
Urbanowicz, Richard A.
Khaiboullina, Svetlana
author_facet Martynova, Ekaterina
Rizvanov, Albert
Urbanowicz, Richard A.
Khaiboullina, Svetlana
author_sort Martynova, Ekaterina
collection PubMed
description Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed.
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spelling pubmed-89695142022-04-01 Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses Martynova, Ekaterina Rizvanov, Albert Urbanowicz, Richard A. Khaiboullina, Svetlana Front Microbiol Microbiology Inflammasomes are cytosolic polyprotein complexes formed in response to various external and internal stimuli, including viral and bacterial antigens. The main product of the inflammasome is active caspase 1 which proteolytically cleaves, releasing functional interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). These cytokines play a central role in shaping immune response to pathogens. In this review, we will focus on the mechanisms of inflammasome activation, as well as their role in development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines IL-1β, IL-18, and IL-33, products of activated inflammasomes, are summarized. Additionally, the role of cytokines released from tissue cells in promoting differentiation of lymphocyte populations is discussed. Frontiers Media S.A. 2022-03-17 /pmc/articles/PMC8969514/ /pubmed/35369454 http://dx.doi.org/10.3389/fmicb.2022.851835 Text en Copyright © 2022 Martynova, Rizvanov, Urbanowicz and Khaiboullina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Martynova, Ekaterina
Rizvanov, Albert
Urbanowicz, Richard A.
Khaiboullina, Svetlana
Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title_full Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title_fullStr Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title_full_unstemmed Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title_short Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses
title_sort inflammasome contribution to the activation of th1, th2, and th17 immune responses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969514/
https://www.ncbi.nlm.nih.gov/pubmed/35369454
http://dx.doi.org/10.3389/fmicb.2022.851835
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