Chloroquine-susceptible and -resistant Plasmodium falciparum strains survive high chloroquine concentrations by becoming dormant but are eliminated by prolonged exposure

BACKGROUND: Plasmodium falciparum strains that are resistant to standard-dose chloroquine can be treated by higher chloroquine concentrations maintained for a longer time in vivo. OBJECTIVES: To determine the relative importance of chloroquine concentrations versus exposure time for elimination of c...

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Detalles Bibliográficos
Autores principales: Ursing, Johan, Johns, Rasmus, Aydin-Schmidt, Berit, Calçada, Carla, Kofoed, Poul-Erik, Ghanchi, Najia Karim, Veiga, Maria Isabel, Rombo, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969533/
https://www.ncbi.nlm.nih.gov/pubmed/35137072
http://dx.doi.org/10.1093/jac/dkac008

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