Analysis of Gene-Environment Interactions Related to Developmental Disorders

Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G [Formula: see text] E) is involved in the etiology of DDs. There are two major approaches to analyze the interaction: genom...

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Detalles Bibliográficos
Autores principales: Nishimura, Yuhei, Kurosawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969575/
https://www.ncbi.nlm.nih.gov/pubmed/35370658
http://dx.doi.org/10.3389/fphar.2022.863664
Descripción
Sumario:Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G [Formula: see text] E) is involved in the etiology of DDs. There are two major approaches to analyze the interaction: genome-wide and candidate gene-based approaches. In this mini-review, we demonstrate how these approaches can be applied to reveal the G [Formula: see text] E related to DDs focusing on zebrafish and mouse models. We also discuss novel approaches to analyze the G [Formula: see text] E associated with DDs.

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