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Retinal Vascular Density on OCT-A and Age-Related Central and Peripheral Hearing Loss in an Italian Older Population

Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these two conditions in older age. We analyzed data on 886 older participants (65 years+, age range: 65-92 years) in the cross-sectional population-b...

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Detalles Bibliográficos
Autores principales: Sardone, Rodolfo, Bortone, Ilaria, Panza, Francesco, Sborgia, Giancarlo, Giuliani, Gianluigi, Pastore, Valentina, Boscia, Francesco, Quaranta, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969659/
http://dx.doi.org/10.1093/geroni/igab046.596
Descripción
Sumario:Age-related hearing loss (ARHL) and retinal vessel changes have both been associated to neurodegeneration/dementia, suggesting a possible link between these two conditions in older age. We analyzed data on 886 older participants (65 years+, age range: 65-92 years) in the cross-sectional population-based Salus in Apulia Study. OCT-A scan was used to measure SVD and DVD of the capillary plexi of the macula in different retinal quadrants. Peripheral ARHL was defined as >40 dB HL of PTA (0.5,1,2, and 4KHz) in the worst ear, and age-related CAPD as <50% at the SSI-ICM test in at least one ear. DVD at the whole retina and at the parafoveal quadrant were inversely associated only with age-related CAPD [OR:0.93; 95%CI: 0.88-0.96 and OR:0.94; 95 CI:0.90-0.99, respectively]. The association of retinal vascular density with age-related CAPD may bring us a further step forward in understanding the biological mechanisms underlying the links between neurodegeneration/dementia and ARHL.