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Gene and drug landing page aggregator
MOTIVATION: Many biological and biomedical researchers commonly search for information about genes and drugs to gather knowledge from these resources. For the most part, such information is served as landing pages in disparate data repositories and web portals. RESULTS: The Gene and Drug Landing Pag...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969666/ https://www.ncbi.nlm.nih.gov/pubmed/35368424 http://dx.doi.org/10.1093/bioadv/vbac013 |
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author | Clarke, Daniel J B Kuleshov, Maxim V Xie, Zhuorui Evangelista, John E Meyers, Marilyn R Kropiwnicki, Eryk Jenkins, Sherry L Ma’ayan, Avi |
author_facet | Clarke, Daniel J B Kuleshov, Maxim V Xie, Zhuorui Evangelista, John E Meyers, Marilyn R Kropiwnicki, Eryk Jenkins, Sherry L Ma’ayan, Avi |
author_sort | Clarke, Daniel J B |
collection | PubMed |
description | MOTIVATION: Many biological and biomedical researchers commonly search for information about genes and drugs to gather knowledge from these resources. For the most part, such information is served as landing pages in disparate data repositories and web portals. RESULTS: The Gene and Drug Landing Page Aggregator (GDLPA) provides users with access to 50 gene-centric and 19 drug-centric repositories, enabling them to retrieve landing pages corresponding to their gene and drug queries. Bringing these resources together into one dashboard that directs users to the landing pages across many resources can help centralize gene- and drug-centric knowledge, as well as raise awareness of available resources that may be missed when using standard search engines. To demonstrate the utility of GDLPA, case studies for the gene klotho and the drug remdesivir were developed. The first case study highlights the potential role of klotho as a drug target for aging and kidney disease, while the second study gathers knowledge regarding approval, usage, and safety for remdesivir, the first approved coronavirus disease 2019 therapeutic. Finally, based on our experience, we provide guidelines for developing effective landing pages for genes and drugs. AVAILABILITY AND IMPLEMENTATION: GDLPA is open source and is available from: https://cfde-gene-pages.cloud/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online. |
format | Online Article Text |
id | pubmed-8969666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89696662022-04-01 Gene and drug landing page aggregator Clarke, Daniel J B Kuleshov, Maxim V Xie, Zhuorui Evangelista, John E Meyers, Marilyn R Kropiwnicki, Eryk Jenkins, Sherry L Ma’ayan, Avi Bioinform Adv Application Note MOTIVATION: Many biological and biomedical researchers commonly search for information about genes and drugs to gather knowledge from these resources. For the most part, such information is served as landing pages in disparate data repositories and web portals. RESULTS: The Gene and Drug Landing Page Aggregator (GDLPA) provides users with access to 50 gene-centric and 19 drug-centric repositories, enabling them to retrieve landing pages corresponding to their gene and drug queries. Bringing these resources together into one dashboard that directs users to the landing pages across many resources can help centralize gene- and drug-centric knowledge, as well as raise awareness of available resources that may be missed when using standard search engines. To demonstrate the utility of GDLPA, case studies for the gene klotho and the drug remdesivir were developed. The first case study highlights the potential role of klotho as a drug target for aging and kidney disease, while the second study gathers knowledge regarding approval, usage, and safety for remdesivir, the first approved coronavirus disease 2019 therapeutic. Finally, based on our experience, we provide guidelines for developing effective landing pages for genes and drugs. AVAILABILITY AND IMPLEMENTATION: GDLPA is open source and is available from: https://cfde-gene-pages.cloud/. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online. Oxford University Press 2022-02-28 /pmc/articles/PMC8969666/ /pubmed/35368424 http://dx.doi.org/10.1093/bioadv/vbac013 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Application Note Clarke, Daniel J B Kuleshov, Maxim V Xie, Zhuorui Evangelista, John E Meyers, Marilyn R Kropiwnicki, Eryk Jenkins, Sherry L Ma’ayan, Avi Gene and drug landing page aggregator |
title | Gene and drug landing page aggregator |
title_full | Gene and drug landing page aggregator |
title_fullStr | Gene and drug landing page aggregator |
title_full_unstemmed | Gene and drug landing page aggregator |
title_short | Gene and drug landing page aggregator |
title_sort | gene and drug landing page aggregator |
topic | Application Note |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969666/ https://www.ncbi.nlm.nih.gov/pubmed/35368424 http://dx.doi.org/10.1093/bioadv/vbac013 |
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