Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers

The COVID-19 pandemic posed unprecedented strain on enrollment to cancer clinical trials and their conduct. Here, we highlight an analysis using information from the National Cancer Institute (NCI) Clinical Trials Reporting Program database to describe enrollment patterns to interventional cancer tr...

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Autores principales: Prindiville, Sheila A., Sarosy, Gisele A., Loose, David, Ciolino, Henry, Doroshow, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969752/
https://www.ncbi.nlm.nih.gov/pubmed/35333495
http://dx.doi.org/10.1097/PPO.0000000000000578
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author Prindiville, Sheila A.
Sarosy, Gisele A.
Loose, David
Ciolino, Henry
Doroshow, James H.
author_facet Prindiville, Sheila A.
Sarosy, Gisele A.
Loose, David
Ciolino, Henry
Doroshow, James H.
author_sort Prindiville, Sheila A.
collection PubMed
description The COVID-19 pandemic posed unprecedented strain on enrollment to cancer clinical trials and their conduct. Here, we highlight an analysis using information from the National Cancer Institute (NCI) Clinical Trials Reporting Program database to describe enrollment patterns to interventional cancer treatment trials at NCI-Designated Cancer Centers during the pandemic. Enrollment to cancer treatment trials at NCI-Designated Cancer Centers decreased precipitously early in the pandemic and has not yet fully returned to the 2019 baseline as of mid-2021. We discuss possible reasons for this and how some of the changes in clinical trial conduct implemented during the pandemic may become part of the standard conduct of NCI-supported clinical trials and broaden access to trials.
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spelling pubmed-89697522022-06-01 Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers Prindiville, Sheila A. Sarosy, Gisele A. Loose, David Ciolino, Henry Doroshow, James H. Cancer J Review Articles The COVID-19 pandemic posed unprecedented strain on enrollment to cancer clinical trials and their conduct. Here, we highlight an analysis using information from the National Cancer Institute (NCI) Clinical Trials Reporting Program database to describe enrollment patterns to interventional cancer treatment trials at NCI-Designated Cancer Centers during the pandemic. Enrollment to cancer treatment trials at NCI-Designated Cancer Centers decreased precipitously early in the pandemic and has not yet fully returned to the 2019 baseline as of mid-2021. We discuss possible reasons for this and how some of the changes in clinical trial conduct implemented during the pandemic may become part of the standard conduct of NCI-supported clinical trials and broaden access to trials. Lippincott Williams & Wilkins 2022 2022-03-28 /pmc/articles/PMC8969752/ /pubmed/35333495 http://dx.doi.org/10.1097/PPO.0000000000000578 Text en Written work prepared by employees of the Federal Government as part of their official duties is, under the U.S. Copyright Act, a “work of the United States Government” for which copyright protection under Title 17 of the United States Code is not available. As such, copyright does not extend to the contributions of employees of the Federal Government. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Review Articles
Prindiville, Sheila A.
Sarosy, Gisele A.
Loose, David
Ciolino, Henry
Doroshow, James H.
Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title_full Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title_fullStr Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title_full_unstemmed Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title_short Patterns of Enrollment in Cancer Treatment Trials During the COVID-19 Pandemic at National Cancer Institute–Designated Cancer Centers
title_sort patterns of enrollment in cancer treatment trials during the covid-19 pandemic at national cancer institute–designated cancer centers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969752/
https://www.ncbi.nlm.nih.gov/pubmed/35333495
http://dx.doi.org/10.1097/PPO.0000000000000578
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