Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation

Overcoming the radiosensitivity of chondrosarcoma (CS), the second most common primary bone tumor, is needed. Radioresistance is attributed to cancer stem cells (CSCs) in many malignancies. Disulfiram (DSF), an FDA-approved anti-alcoholism drug, complexed with Cu (DSF/Cu) can radiosensitize epitheli...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Michelakos, Theodoros, Wang, Bing, Shang, Zikun, DeLeo, Albert B., Duan, Zhenfeng, Hornicek, Francis J., Schwab, Joseph H., Wang, Xinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969896/
https://www.ncbi.nlm.nih.gov/pubmed/33582212
http://dx.doi.org/10.1016/j.canlet.2021.02.002

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