Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling

[Image: see text] The large family of polypeptide GalNAc-transferases (GalNAc-Ts) controls with precision how GalNAc O-glycans are added in the tandem repeat regions of mucins (e.g., MUC1). However, the structural features behind the creation of well-defined and clustered patterns of O-glycans in mu...

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Detalles Bibliográficos
Autores principales: Coelho, Helena, Rivas, Matilde de las, Grosso, Ana S., Diniz, Ana, Soares, Cátia O., Francisco, Rodrigo A., Dias, Jorge S., Compañon, Ismael, Sun, Lingbo, Narimatsu, Yoshiki, Vakhrushev, Sergey Y., Clausen, Henrik, Cabrita, Eurico J., Jiménez-Barbero, Jesús, Corzana, Francisco, Hurtado-Guerrero, Ramon, Marcelo, Filipa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969996/
https://www.ncbi.nlm.nih.gov/pubmed/35373202
http://dx.doi.org/10.1021/jacsau.1c00529

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