Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure

[Image: see text] The paradigmatic disordered protein tau plays an important role in neuronal function and neurodegenerative diseases. To disentangle the factors controlling the balance between functional and disease-associated conformational states, we build a structural ensemble of the tau K18 fra...

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Detalles Bibliográficos
Autores principales: Stelzl, Lukas S., Pietrek, Lisa M., Holla, Andrea, Oroz, Javier, Sikora, Mateusz, Köfinger, Jürgen, Schuler, Benjamin, Zweckstetter, Markus, Hummer, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970000/
https://www.ncbi.nlm.nih.gov/pubmed/35373198
http://dx.doi.org/10.1021/jacsau.1c00536

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