Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells

In Parkinson’s disease (PD), there is accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. The cytokines TNF-α, IL-1β and IL-6 induce accumulation of degradation products of the amyloid precursor protein (APP) combined with heparan sulfate (HS) chains rele...

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Detalles Bibliográficos
Autores principales: Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970428/
https://www.ncbi.nlm.nih.gov/pubmed/34939110
http://dx.doi.org/10.1093/glycob/cwab126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970428/
https://www.ncbi.nlm.nih.gov/pubmed/34939110
http://dx.doi.org/10.1093/glycob/cwab126

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