Calculating and comparing codon usage values in rare disease genes highlights codon clustering with disease-and tissue- specific hierarchy

We designed a novel strategy to define codon usage bias (CUB) in 6 specific small cohorts of human genes. We calculated codon usage (CU) values in 29 non-disease-causing (NDC) and 31 disease-causing (DC) human genes which are highly expressed in 3 distinct tissues, kidney, muscle, and skin. We appli...

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Detalles Bibliográficos
Autores principales: Rossi, Rachele, Fang, Mingyan, Zhu, Lin, Jiang, Chongyi, Yu, Cong, Flesia, Cristina, Nie, Chao, Li, Wenyan, Ferlini, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970475/
https://www.ncbi.nlm.nih.gov/pubmed/35358230
http://dx.doi.org/10.1371/journal.pone.0265469

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