Cargando…

Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis

INTRODUCTION: The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. However, these results were contradictory and just focused on one or two autoimmune diseases. The present study aims to examine the possible association between rs3746444 polymorphism an...

Descripción completa

Detalles Bibliográficos
Autores principales: Kong, Xiangjian, Diao, Shuling, Xu, Huipu, Sun, Junming, Ma, Baoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970500/
https://www.ncbi.nlm.nih.gov/pubmed/35358276
http://dx.doi.org/10.1371/journal.pone.0266265
_version_ 1784679470033010688
author Kong, Xiangjian
Diao, Shuling
Xu, Huipu
Sun, Junming
Ma, Baoxin
author_facet Kong, Xiangjian
Diao, Shuling
Xu, Huipu
Sun, Junming
Ma, Baoxin
author_sort Kong, Xiangjian
collection PubMed
description INTRODUCTION: The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. However, these results were contradictory and just focused on one or two autoimmune diseases. The present study aims to examine the possible association between rs3746444 polymorphism and the risk of autoimmune diseases. METHODS: The studies that evaluated the association between miRNA-499 gene polymorphism and autoimmune diseases were retrieved. Five different genetic models were used to evaluate the association. The random-effects model was used to pool the effect sizes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the associations. Stratification analyses were performed by ethnicity and type of autoimmune diseases. False-positive report probability (FPRP) was performed for determining noteworthy associations. RESULTS: Seventeen articles (twenty studies) involving 4,376 cases and 4,991 controls were identified and included in our meta-analysis. The pooled ORs of all eligible case-control studies indicated a significant association between miRNA-499 gene polymorphism and autoimmune diseases: (T vs. C: OR = 0.877; 95% CI: 0.774, 0.993; P = 0.039). Stratified analysis indicated a significant association across both Caucasian (TT vs. TC+CC: OR = 0.779; 95% CI: 0.622, 0.976; P = 0.030) and Asian (T vs. C: OR = 0.895; 95% CI: 0.808, 0.992; P = 0.035) populations. There was also a significant association in Behcet’s disease, rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis populations. CONCLUSIONS: Our meta-analysis suggested that the miRNA-499 rs3746444 polymorphism was associated with an elevated risk of autoimmune diseases in the overall analysis as well as Caucasian and Asian populations.
format Online
Article
Text
id pubmed-8970500
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-89705002022-04-01 Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis Kong, Xiangjian Diao, Shuling Xu, Huipu Sun, Junming Ma, Baoxin PLoS One Research Article INTRODUCTION: The association between miRNA-499 rs3746444 and a variety of autoimmune diseases has been reported. However, these results were contradictory and just focused on one or two autoimmune diseases. The present study aims to examine the possible association between rs3746444 polymorphism and the risk of autoimmune diseases. METHODS: The studies that evaluated the association between miRNA-499 gene polymorphism and autoimmune diseases were retrieved. Five different genetic models were used to evaluate the association. The random-effects model was used to pool the effect sizes. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the associations. Stratification analyses were performed by ethnicity and type of autoimmune diseases. False-positive report probability (FPRP) was performed for determining noteworthy associations. RESULTS: Seventeen articles (twenty studies) involving 4,376 cases and 4,991 controls were identified and included in our meta-analysis. The pooled ORs of all eligible case-control studies indicated a significant association between miRNA-499 gene polymorphism and autoimmune diseases: (T vs. C: OR = 0.877; 95% CI: 0.774, 0.993; P = 0.039). Stratified analysis indicated a significant association across both Caucasian (TT vs. TC+CC: OR = 0.779; 95% CI: 0.622, 0.976; P = 0.030) and Asian (T vs. C: OR = 0.895; 95% CI: 0.808, 0.992; P = 0.035) populations. There was also a significant association in Behcet’s disease, rheumatoid arthritis, systemic lupus erythematosus, and ulcerative colitis populations. CONCLUSIONS: Our meta-analysis suggested that the miRNA-499 rs3746444 polymorphism was associated with an elevated risk of autoimmune diseases in the overall analysis as well as Caucasian and Asian populations. Public Library of Science 2022-03-31 /pmc/articles/PMC8970500/ /pubmed/35358276 http://dx.doi.org/10.1371/journal.pone.0266265 Text en © 2022 Kong et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kong, Xiangjian
Diao, Shuling
Xu, Huipu
Sun, Junming
Ma, Baoxin
Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title_full Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title_fullStr Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title_full_unstemmed Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title_short Association between miRNA-499 gene polymorphism and autoimmune diseases: A meta-analysis
title_sort association between mirna-499 gene polymorphism and autoimmune diseases: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970500/
https://www.ncbi.nlm.nih.gov/pubmed/35358276
http://dx.doi.org/10.1371/journal.pone.0266265
work_keys_str_mv AT kongxiangjian associationbetweenmirna499genepolymorphismandautoimmunediseasesametaanalysis
AT diaoshuling associationbetweenmirna499genepolymorphismandautoimmunediseasesametaanalysis
AT xuhuipu associationbetweenmirna499genepolymorphismandautoimmunediseasesametaanalysis
AT sunjunming associationbetweenmirna499genepolymorphismandautoimmunediseasesametaanalysis
AT mabaoxin associationbetweenmirna499genepolymorphismandautoimmunediseasesametaanalysis