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Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

Several mutations identified in phospholamban (PLN) have been linked to familial dilated cardiomyopathy (DCM) and heart failure, yet the underlying molecular mechanism remains controversial. PLN interacts with sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) and regulates calcium uptake, which is m...

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Detalles Bibliográficos
Autores principales:	Qin, Juan, Zhang, Jingfeng, Lin, Lianyun, Haji-Ghassemi, Omid, Lin, Zhi, Woycechowsky, Kenneth J, Van Petegem, Filip, Zhang, Yan, Yuchi, Zhiguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970585/ https://www.ncbi.nlm.nih.gov/pubmed/35297759 http://dx.doi.org/10.7554/eLife.75346

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