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Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function

Glutamate is the predominant excitatory neurotransmitter in the mammalian central nervous system (CNS). Excitatory amino acid transporters (EAATs) regulate extracellular glutamate by transporting it into cells, mostly glia, to terminate neurotransmission and to avoid neurotoxicity. EAATs are also ch...

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Detalles Bibliográficos
Autores principales:	Wu, Qianyi, Akhter, Azman, Pant, Shashank, Cho, Eunjoo, Zhu, Jin Xin, Garner, Alastair, Ohyama, Tomoko, Tajkhorshid, Emad, van Meyel, Donald J., Ryan, Renae M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970671/ https://www.ncbi.nlm.nih.gov/pubmed/35167492 http://dx.doi.org/10.1172/JCI154891

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