Hepatic FoxOs link insulin signaling with plasma lipoprotein metabolism through an apolipoprotein M/sphingosine-1-phosphate pathway

Multiple beneficial cardiovascular effects of HDL depend on sphingosine-1-phosphate (S1P). S1P associates with HDL by binding to apolipoprotein M (ApoM). Insulin resistance is a major driver of dyslipidemia and cardiovascular risk. However, the mechanisms linking alterations in insulin signaling wit...

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Detalles Bibliográficos
Autores principales: Izquierdo, María Concepción, Shanmugarajah, Niroshan, Lee, Samuel X., Kraakman, Michael J., Westerterp, Marit, Kitamoto, Takumi, Harris, Michael, Cook, Joshua R., Gusarova, Galina A., Zhong, Kendra, Marbuary, Elijah, O-Sullivan, InSug, Rasmus, Nikolaus, Camastra, Stefania, Unterman, Terry G., Ferrannini, Ele, Hurwitz, Barry E., Haeusler, Rebecca A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970673/
https://www.ncbi.nlm.nih.gov/pubmed/35104242
http://dx.doi.org/10.1172/JCI146219

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