IL-9/STAT3/fatty acid oxidation–mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity

CD8(+) T cell longevity regulated by metabolic activity plays important roles in cancer immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8(+) Tc9 (cytotoxic T lymphocyte subset 9) cells exert greater persistence and antitumor efficacy than Tc1 cells, the underlying mechanism...

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Detalles Bibliográficos
Autores principales: Xiao, Liuling, Ma, Xingzhe, Ye, Lingqun, Su, Pan, Xiong, Wei, Bi, Enguang, Wang, Qiang, Xian, Miao, Yang, Maojie, Qian, Jianfei, Yi, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970676/
https://www.ncbi.nlm.nih.gov/pubmed/35192544
http://dx.doi.org/10.1172/JCI153247

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