Tankyrase represses autoinflammation through the attenuation of TLR2 signaling

Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a member of the poly(ADP-ribose) polymerase (PARP) family, negatively regulates TLR2 signaling. We show that mice lacking tankyrase in myeloid...

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Detalles Bibliográficos
Autores principales: Matsumoto, Yoshinori, Dimitriou, Ioannis D., La Rose, Jose, Lim, Melissa, Camilleri, Susan, Law, Napoleon, Adissu, Hibret A., Tong, Jiefei, Moran, Michael F., Chruscinski, Andrzej, He, Fang, Asano, Yosuke, Katsuyama, Takayuki, Sada, Ken-ei, Wada, Jun, Rottapel, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970677/
https://www.ncbi.nlm.nih.gov/pubmed/35362478
http://dx.doi.org/10.1172/JCI140869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970677/
https://www.ncbi.nlm.nih.gov/pubmed/35362478
http://dx.doi.org/10.1172/JCI140869

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