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Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies

An increasing body of evidence connects non-alcoholic fatty liver disease (NAFLD) to hypertension. The objective of this systematic review and meta-analysis was to estimate the nature and magnitude of the association between NAFLD and hypertension. We systematically searched PubMed, Embase, Cochrane...

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Autores principales: Li, Gerui, Peng, Yuanyuan, Chen, Ze, Li, Hang, Liu, Danli, Ye, Xujun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970889/
https://www.ncbi.nlm.nih.gov/pubmed/35371259
http://dx.doi.org/10.1155/2022/8463640
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author Li, Gerui
Peng, Yuanyuan
Chen, Ze
Li, Hang
Liu, Danli
Ye, Xujun
author_facet Li, Gerui
Peng, Yuanyuan
Chen, Ze
Li, Hang
Liu, Danli
Ye, Xujun
author_sort Li, Gerui
collection PubMed
description An increasing body of evidence connects non-alcoholic fatty liver disease (NAFLD) to hypertension. The objective of this systematic review and meta-analysis was to estimate the nature and magnitude of the association between NAFLD and hypertension. We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for observational studies published up to May 1, 2021. Cohort studies that reported data on the association between NAFLD and incident hypertension or between hypertension and incident NAFLD were included. We used random-effects models to conduct meta-analysis on the measures of association from individual studies. A total of 11 studies were eligible for inclusion, among which 4 studies including 25,260 participants reported the association between hypertension and new-onset NAFLD. The presence of hypertension was significantly associated with an increased risk of incident NAFLD (HR 1.63, 95% CI: 1.41–1.88; I(2) = 37.6%). On the other hand, 9 studies with data on 46,487 participants analyzed the effects of NAFLD on incident hypertension. Pooled analysis showed that the presence of NAFLD was significantly associated with an increased incidence of hypertension (HR 1.55, 95% CI: 1.29–1.87; I(2) = 80.5%). There was significant heterogeneity among the studies in this analysis (p < 0.01). Sensitivity analyses showed that the magnitude of the association was significantly different in subgroups stratified by a mean age of participants and geographical location, which explains part of the heterogeneity. In conclusion, this meta-analysis indicates the existence of a bidirectional relationship between NAFLD and hypertension independent of traditional cardiometabolic risk factors.
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spelling pubmed-89708892022-04-01 Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies Li, Gerui Peng, Yuanyuan Chen, Ze Li, Hang Liu, Danli Ye, Xujun Int J Endocrinol Review Article An increasing body of evidence connects non-alcoholic fatty liver disease (NAFLD) to hypertension. The objective of this systematic review and meta-analysis was to estimate the nature and magnitude of the association between NAFLD and hypertension. We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for observational studies published up to May 1, 2021. Cohort studies that reported data on the association between NAFLD and incident hypertension or between hypertension and incident NAFLD were included. We used random-effects models to conduct meta-analysis on the measures of association from individual studies. A total of 11 studies were eligible for inclusion, among which 4 studies including 25,260 participants reported the association between hypertension and new-onset NAFLD. The presence of hypertension was significantly associated with an increased risk of incident NAFLD (HR 1.63, 95% CI: 1.41–1.88; I(2) = 37.6%). On the other hand, 9 studies with data on 46,487 participants analyzed the effects of NAFLD on incident hypertension. Pooled analysis showed that the presence of NAFLD was significantly associated with an increased incidence of hypertension (HR 1.55, 95% CI: 1.29–1.87; I(2) = 80.5%). There was significant heterogeneity among the studies in this analysis (p < 0.01). Sensitivity analyses showed that the magnitude of the association was significantly different in subgroups stratified by a mean age of participants and geographical location, which explains part of the heterogeneity. In conclusion, this meta-analysis indicates the existence of a bidirectional relationship between NAFLD and hypertension independent of traditional cardiometabolic risk factors. Hindawi 2022-03-24 /pmc/articles/PMC8970889/ /pubmed/35371259 http://dx.doi.org/10.1155/2022/8463640 Text en Copyright © 2022 Gerui Li et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Gerui
Peng, Yuanyuan
Chen, Ze
Li, Hang
Liu, Danli
Ye, Xujun
Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title_full Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title_fullStr Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title_full_unstemmed Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title_short Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies
title_sort bidirectional association between hypertension and nafld: a systematic review and meta-analysis of observational studies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970889/
https://www.ncbi.nlm.nih.gov/pubmed/35371259
http://dx.doi.org/10.1155/2022/8463640
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