Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality

BACKGROUND: Severe COVID-19 T-cell lymphopenia is more common among older adults and entails poor prognosis. Offsetting the decline in T-cell count during COVID-19 demands fast and massive T-cell clonal expansion, which is telomere length (TL)-dependent. METHODS: We developed a model of TL-dependent...

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Detalles Bibliográficos
Autores principales: Anderson, James J., Susser, Ezra, Arbeev, Konstantin G., Yashin, Anatoliy I., Levy, Daniel, Verhulst, Simon, Aviv, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970968/
https://www.ncbi.nlm.nih.gov/pubmed/35367774
http://dx.doi.org/10.1016/j.ebiom.2022.103978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970968/
https://www.ncbi.nlm.nih.gov/pubmed/35367774
http://dx.doi.org/10.1016/j.ebiom.2022.103978

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