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Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam
Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with chronic hepatitis B at a General Hospital in Northern Vietnam. The longitudi...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971045/ https://www.ncbi.nlm.nih.gov/pubmed/35392005 http://dx.doi.org/10.18999/nagjms.84.1.19 |
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author | Luu, Ngoc Minh Nguyen, Thi Kim Thuy Vu, Thu Trang Dinh, Thai Son Luu, Ngoc Hoat Do, Thi Thanh Toan Nguyen, Van Son Ha, Thi Bich Van Nguyen, Dinh Chuc Tran, Thi Huong Phung, Thi Thuy Hang Duong, Xuan Phuong Khuong, Quynh Long Nguyen, Thi Thu Trang Saw, Yu Mon Hoang, Thi Ngoc Anh Nguyen, Thi Nhan |
author_facet | Luu, Ngoc Minh Nguyen, Thi Kim Thuy Vu, Thu Trang Dinh, Thai Son Luu, Ngoc Hoat Do, Thi Thanh Toan Nguyen, Van Son Ha, Thi Bich Van Nguyen, Dinh Chuc Tran, Thi Huong Phung, Thi Thuy Hang Duong, Xuan Phuong Khuong, Quynh Long Nguyen, Thi Thu Trang Saw, Yu Mon Hoang, Thi Ngoc Anh Nguyen, Thi Nhan |
author_sort | Luu, Ngoc Minh |
collection | PubMed |
description | Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with chronic hepatitis B at a General Hospital in Northern Vietnam. The longitudinal study included 55 eligible subjects diagnosed Hepatitis-B-virus. Dependent variable was the aspartate aminotransferase/platelet ratio index and we collected some demographic variables and disease related and behaviour variables. Bayesian Model Averaging was used to select variables into model. Mixed-effect linear models were used to evaluate the change of the aspartate aminotransferase/platelet ratio index over time and identify related factors. the aspartate aminotransferase/platelet ratio index differences between examinations, age of participants, working status were statistically significant. This pattern indicated that the average the aspartate aminotransferase/platelet ratio index of the population decreased by 0.005 (95% CI=-0.009; –0.001) after each patient’s visit, and increased by 0.013 if the patient’s age increased by 1 year (95% CI=0.005; 0.0219). For non-working patients, the aspartate aminotransferase/platelet ratio index was lower, coefficient was –0.054 (95% CI=-0.108; 0.001). Other variables such as gender, education level, time for disease detection, drinking tea, alcohol consumption, forgetting to take medicine and the aspartate aminotransferase/platelet ratio index were not significantly different. The study showed that the majority of study subjects had average the aspartate aminotransferase/platelet ratio index, and were relatively well controlled and treated during the study. Age and working status are factors that influence the the aspartate aminotransferase/platelet ratio index. |
format | Online Article Text |
id | pubmed-8971045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-89710452022-04-06 Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam Luu, Ngoc Minh Nguyen, Thi Kim Thuy Vu, Thu Trang Dinh, Thai Son Luu, Ngoc Hoat Do, Thi Thanh Toan Nguyen, Van Son Ha, Thi Bich Van Nguyen, Dinh Chuc Tran, Thi Huong Phung, Thi Thuy Hang Duong, Xuan Phuong Khuong, Quynh Long Nguyen, Thi Thu Trang Saw, Yu Mon Hoang, Thi Ngoc Anh Nguyen, Thi Nhan Nagoya J Med Sci Original Paper Evaluation of liver fibrosis is necessary to make the therapeutic decision and assess the prognosis of CHB patients. The current study aimed to describe the progression and identify some influencing factors in patients with chronic hepatitis B at a General Hospital in Northern Vietnam. The longitudinal study included 55 eligible subjects diagnosed Hepatitis-B-virus. Dependent variable was the aspartate aminotransferase/platelet ratio index and we collected some demographic variables and disease related and behaviour variables. Bayesian Model Averaging was used to select variables into model. Mixed-effect linear models were used to evaluate the change of the aspartate aminotransferase/platelet ratio index over time and identify related factors. the aspartate aminotransferase/platelet ratio index differences between examinations, age of participants, working status were statistically significant. This pattern indicated that the average the aspartate aminotransferase/platelet ratio index of the population decreased by 0.005 (95% CI=-0.009; –0.001) after each patient’s visit, and increased by 0.013 if the patient’s age increased by 1 year (95% CI=0.005; 0.0219). For non-working patients, the aspartate aminotransferase/platelet ratio index was lower, coefficient was –0.054 (95% CI=-0.108; 0.001). Other variables such as gender, education level, time for disease detection, drinking tea, alcohol consumption, forgetting to take medicine and the aspartate aminotransferase/platelet ratio index were not significantly different. The study showed that the majority of study subjects had average the aspartate aminotransferase/platelet ratio index, and were relatively well controlled and treated during the study. Age and working status are factors that influence the the aspartate aminotransferase/platelet ratio index. Nagoya University 2022-02 /pmc/articles/PMC8971045/ /pubmed/35392005 http://dx.doi.org/10.18999/nagjms.84.1.19 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Paper Luu, Ngoc Minh Nguyen, Thi Kim Thuy Vu, Thu Trang Dinh, Thai Son Luu, Ngoc Hoat Do, Thi Thanh Toan Nguyen, Van Son Ha, Thi Bich Van Nguyen, Dinh Chuc Tran, Thi Huong Phung, Thi Thuy Hang Duong, Xuan Phuong Khuong, Quynh Long Nguyen, Thi Thu Trang Saw, Yu Mon Hoang, Thi Ngoc Anh Nguyen, Thi Nhan Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title | Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title_full | Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title_fullStr | Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title_full_unstemmed | Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title_short | Progression of liver fibrosis and associated factors among chronic hepatitis B patients at a general hospital in Northern Vietnam |
title_sort | progression of liver fibrosis and associated factors among chronic hepatitis b patients at a general hospital in northern vietnam |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971045/ https://www.ncbi.nlm.nih.gov/pubmed/35392005 http://dx.doi.org/10.18999/nagjms.84.1.19 |
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