Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review

Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, name...

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Detalles Bibliográficos
Autores principales: Alsayed, Badr A, Mir, Rashid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971094/
https://www.ncbi.nlm.nih.gov/pubmed/35371838
http://dx.doi.org/10.7759/cureus.23636
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author Alsayed, Badr A
Mir, Rashid
author_facet Alsayed, Badr A
Mir, Rashid
author_sort Alsayed, Badr A
collection PubMed
description Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, namely, angiotensin-converting enzyme 2 (ACE2-rs4646994 I/D) gene, glutathione S-transferase (GST) M1 and T1 gene, and miR-423 rs6505162 C>A gene polymorphism. Results showed that the ACE-DD genotype of ACE2, (GSTM1+/+) (GSTT1−/−) genotype of GST gene, and CA genotype (heterozygosity) of miR-423 rs6505162 genes, which were found in the patient, could be independent risk factors of severe COVID-19, even without comorbidities. 
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spelling pubmed-89710942022-04-01 Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review Alsayed, Badr A Mir, Rashid Cureus Genetics Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, namely, angiotensin-converting enzyme 2 (ACE2-rs4646994 I/D) gene, glutathione S-transferase (GST) M1 and T1 gene, and miR-423 rs6505162 C>A gene polymorphism. Results showed that the ACE-DD genotype of ACE2, (GSTM1+/+) (GSTT1−/−) genotype of GST gene, and CA genotype (heterozygosity) of miR-423 rs6505162 genes, which were found in the patient, could be independent risk factors of severe COVID-19, even without comorbidities.  Cureus 2022-03-30 /pmc/articles/PMC8971094/ /pubmed/35371838 http://dx.doi.org/10.7759/cureus.23636 Text en Copyright © 2022, Alsayed et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Alsayed, Badr A
Mir, Rashid
Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title_full Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title_fullStr Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title_full_unstemmed Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title_short Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review
title_sort severe covid-19 pneumonia and genetic susceptibility: a case report and literature review
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971094/
https://www.ncbi.nlm.nih.gov/pubmed/35371838
http://dx.doi.org/10.7759/cureus.23636
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