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Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study

The association between blood transfusion and the occurrence of de novo HLA donor specific antibodies (DSA) after kidney transplantation remains controversial. In this single-center observational study, we examined the association between early blood transfusion, i.e. before 1-month post-transplanta...

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Autores principales: Khedjat, Kahina, Lenain, Rémi, Hamroun, Aghilès, Baes, Dulciane, Top, Isabelle, Labalette, Myriam, Lopez, Benjamin, Van Triempont, Marine, Provôt, François, Frimat, Marie, Gibier, Jean-Baptiste, Hazzan, Marc, Maanaoui, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971186/
https://www.ncbi.nlm.nih.gov/pubmed/35368637
http://dx.doi.org/10.3389/ti.2022.10279
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author Khedjat, Kahina
Lenain, Rémi
Hamroun, Aghilès
Baes, Dulciane
Top, Isabelle
Labalette, Myriam
Lopez, Benjamin
Van Triempont, Marine
Provôt, François
Frimat, Marie
Gibier, Jean-Baptiste
Hazzan, Marc
Maanaoui, Mehdi
author_facet Khedjat, Kahina
Lenain, Rémi
Hamroun, Aghilès
Baes, Dulciane
Top, Isabelle
Labalette, Myriam
Lopez, Benjamin
Van Triempont, Marine
Provôt, François
Frimat, Marie
Gibier, Jean-Baptiste
Hazzan, Marc
Maanaoui, Mehdi
author_sort Khedjat, Kahina
collection PubMed
description The association between blood transfusion and the occurrence of de novo HLA donor specific antibodies (DSA) after kidney transplantation remains controversial. In this single-center observational study, we examined the association between early blood transfusion, i.e. before 1-month post-transplantation, and the risk of DSA occurrence, using Luminex based-methods. In total, 1,424 patients with a minimum of 1-month follow-up were evaluated between January 2007 and December 2018. During a median time of follow-up of 4.52 years, we observed 258 recipients who had at least one blood transfusion during the first month post-transplantation. At baseline, recipients in the transfused group were significant older, more sensitized against HLA class I and class II antibodies and had a higher 1-month serum creatinine. Cox proportional hazards regression analyses did not show any significant association between blood transfusion and the risk of de novo DSA occurrence (1.35 [0.86–2.11], p = 0.19), the risk of rejection (HR = 1.33 [0.94–1.89], p = 0.11), or the risk of graft loss (HR = 1.04 [0.73–1.50], p = 0.82). These data suggest then that blood transfusion may not be limited when required in the early phase of transplantation, and may not impact long-term outcomes.
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spelling pubmed-89711862022-04-02 Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study Khedjat, Kahina Lenain, Rémi Hamroun, Aghilès Baes, Dulciane Top, Isabelle Labalette, Myriam Lopez, Benjamin Van Triempont, Marine Provôt, François Frimat, Marie Gibier, Jean-Baptiste Hazzan, Marc Maanaoui, Mehdi Transpl Int Health Archive The association between blood transfusion and the occurrence of de novo HLA donor specific antibodies (DSA) after kidney transplantation remains controversial. In this single-center observational study, we examined the association between early blood transfusion, i.e. before 1-month post-transplantation, and the risk of DSA occurrence, using Luminex based-methods. In total, 1,424 patients with a minimum of 1-month follow-up were evaluated between January 2007 and December 2018. During a median time of follow-up of 4.52 years, we observed 258 recipients who had at least one blood transfusion during the first month post-transplantation. At baseline, recipients in the transfused group were significant older, more sensitized against HLA class I and class II antibodies and had a higher 1-month serum creatinine. Cox proportional hazards regression analyses did not show any significant association between blood transfusion and the risk of de novo DSA occurrence (1.35 [0.86–2.11], p = 0.19), the risk of rejection (HR = 1.33 [0.94–1.89], p = 0.11), or the risk of graft loss (HR = 1.04 [0.73–1.50], p = 0.82). These data suggest then that blood transfusion may not be limited when required in the early phase of transplantation, and may not impact long-term outcomes. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8971186/ /pubmed/35368637 http://dx.doi.org/10.3389/ti.2022.10279 Text en Copyright © 2022 Khedjat, Lenain, Hamroun, Baes, Top, Labalette, Lopez, Van Triempont, Provôt, Frimat, Gibier, Hazzan and Maanaoui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Khedjat, Kahina
Lenain, Rémi
Hamroun, Aghilès
Baes, Dulciane
Top, Isabelle
Labalette, Myriam
Lopez, Benjamin
Van Triempont, Marine
Provôt, François
Frimat, Marie
Gibier, Jean-Baptiste
Hazzan, Marc
Maanaoui, Mehdi
Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title_full Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title_fullStr Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title_full_unstemmed Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title_short Post-Transplantation Early Blood Transfusion and Kidney Allograft Outcomes: A Single-Center Observational Study
title_sort post-transplantation early blood transfusion and kidney allograft outcomes: a single-center observational study
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971186/
https://www.ncbi.nlm.nih.gov/pubmed/35368637
http://dx.doi.org/10.3389/ti.2022.10279
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