Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network

Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and...

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Autores principales: Li, Chengshun, Li, Xiaolan, Jiang, Ziping, Wang, Dongxu, Sun, Liqun, Li, Jiaqi, Han, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971295/
https://www.ncbi.nlm.nih.gov/pubmed/35371996
http://dx.doi.org/10.3389/fonc.2022.842790
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author Li, Chengshun
Li, Xiaolan
Jiang, Ziping
Wang, Dongxu
Sun, Liqun
Li, Jiaqi
Han, Yang
author_facet Li, Chengshun
Li, Xiaolan
Jiang, Ziping
Wang, Dongxu
Sun, Liqun
Li, Jiaqi
Han, Yang
author_sort Li, Chengshun
collection PubMed
description Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids.
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spelling pubmed-89712952022-04-02 Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network Li, Chengshun Li, Xiaolan Jiang, Ziping Wang, Dongxu Sun, Liqun Li, Jiaqi Han, Yang Front Oncol Oncology Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8971295/ /pubmed/35371996 http://dx.doi.org/10.3389/fonc.2022.842790 Text en Copyright © 2022 Li, Li, Jiang, Wang, Sun, Li and Han https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Chengshun
Li, Xiaolan
Jiang, Ziping
Wang, Dongxu
Sun, Liqun
Li, Jiaqi
Han, Yang
Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title_full Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title_fullStr Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title_full_unstemmed Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title_short Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network
title_sort flavonoids inhibit cancer by regulating the competing endogenous rna network
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971295/
https://www.ncbi.nlm.nih.gov/pubmed/35371996
http://dx.doi.org/10.3389/fonc.2022.842790
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