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Peroxiredoxin 6 Modulates Insulin Secretion and Beta Cell Death via a Mitochondrial Dynamic Network

In pancreatic beta cells, mitochondrial metabolism controls glucose-stimulated insulin secretion (GSIS) by ATP production, redox signaling, and calcium (Ca(2+)) handling. Previously, we demonstrated that knockout mice for peroxiredoxin 6 (Prdx6(-/-) ), an antioxidant enzyme with both peroxidase and...

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Detalles Bibliográficos
Autores principales:	Pacifici, Francesca, Della-Morte, David, Capuani, Barbara, Coppola, Andrea, Scioli, Maria Giovanna, Donadel, Giulia, Andreadi, Aikaterini, Ciccosanti, Fabiola, Fimia, Gian Maria, Bellia, Alfonso, Orlandi, Augusto, Lauro, Davide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971298/ https://www.ncbi.nlm.nih.gov/pubmed/35370943 http://dx.doi.org/10.3389/fendo.2022.842575

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