Inhibition of HDACs reduces Ewing sarcoma tumor growth through EWS-FLI1 protein destabilization

Oncogenic transcription factors lacking enzymatic activity or targetable binding pockets are typically considered “undruggable”. An example is provided by the EWS-FLI1 oncoprotein, whose continuous expression and activity as transcription factor are critically required for Ewing sarcoma tumor format...

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Detalles Bibliográficos
Autores principales: Pedot, Gloria, Marques, Joana Graça, Ambühl, Philip P., Wachtel, Marco, Kasper, Stephanie, Ngo, Quy A., Niggli, Felix K., Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971315/
https://www.ncbi.nlm.nih.gov/pubmed/35366465
http://dx.doi.org/10.1016/j.neo.2022.100784

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