Hypoxia-directed tumor targeting of CRISPR-Cas9 and HSV-TK suicide gene therapy using lipid nanoparticles

Hypoxia is a characteristic feature of solid tumors that contributes to tumor aggressiveness and is associated with resistance to cancer therapy. The hypoxia inducible factor-1 (HIF-1) transcription factor complex mediates hypoxia-specific gene expression by binding to hypoxia-responsive element (HR...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Alicia, Morris, Kevin V., Shevchenko, Galina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971340/
https://www.ncbi.nlm.nih.gov/pubmed/35402634
http://dx.doi.org/10.1016/j.omtm.2022.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971340/
https://www.ncbi.nlm.nih.gov/pubmed/35402634
http://dx.doi.org/10.1016/j.omtm.2022.03.008

Ejemplares similares