Improving the specificity of nucleic acid detection with endonuclease-actuated degradation

Nucleic acid detection is essential for numerous biomedical applications, but often requires complex protocols and/or suffers false-positive readouts. Here, we describe SENTINEL, an approach that combines isothermal amplification with a sequence-specific degradation method to detect nucleic acids wi...

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Detalles Bibliográficos
Autores principales: Zou, Roger S., Gavrilov, Momcilo, Liu, Yang, Rasoloson, Dominique, Conte, Madison, Hardick, Justin, Shen, Leo, Chen, Siqi, Pekosz, Andrew, Seydoux, Geraldine, Manabe, Yukari C., Ha, Taekjip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971390/
https://www.ncbi.nlm.nih.gov/pubmed/35361863
http://dx.doi.org/10.1038/s42003-022-03242-x

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