IL-1β-activated mTORC2 promotes accumulation of IFN-γ(+) γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis

Liver fibrosis represents a severe stage of liver damage, with hallmarks of inflammation, hepatic stellate cell activation, and extracellular matrix accumulation. Although previous studies demonstrated γδ T cells are involved in liver fibrosis, the precise role and mechanisms of γδ T cells migrating...

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Detalles Bibliográficos
Autores principales: Liu, Qihui, Yang, Quanli, Wu, Zengfeng, Chen, Yanfang, Xu, Miaomiao, Zhang, Hua, Zhao, Jiliang, Liu, Zonghua, Guan, Zerong, Luo, Jing, Li, Zhi-yong, Sun, Guodong, Wen, Qiong, Xu, Yan, Li, Zhenhua, Chen, Kebing, Ben, Xiaosong, He, Wanchun, Li, Xueshi, Yin, Zhinan, Hao, Jianlei, Lu, Ligong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971410/
https://www.ncbi.nlm.nih.gov/pubmed/35361750
http://dx.doi.org/10.1038/s41419-022-04739-3

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