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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

Colorectal cancer (CRC) ranks third among the most frequent malignancies and represents the second most common cause of cancer-related deaths worldwide. By interfering with the DNA replication process of cancer cells, several chemotherapeutic molecules used in CRC therapy induce replication stress (...

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Detalles Bibliográficos
Autores principales:	Egger, Tom, Bordignon, Benoît, Coquelle, Arnaud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971416/ https://www.ncbi.nlm.nih.gov/pubmed/35361811 http://dx.doi.org/10.1038/s41598-022-09308-4

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