SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications

The abnormal activation of signal transducer and activator of transcription (STAT) protein family is recognized as cause or driving force behind multiple diseases progression. Therefore, searching for potential treatment strategy is pursued by multiple scientific groups. We consider that providing c...

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Autores principales: Plens-Gałąska, Martyna, Woźniak, Tomasz, Wesoły, Joanna, Bluyssen, Hans A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971479/
https://www.ncbi.nlm.nih.gov/pubmed/35361787
http://dx.doi.org/10.1038/s41597-022-01243-3
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author Plens-Gałąska, Martyna
Woźniak, Tomasz
Wesoły, Joanna
Bluyssen, Hans A. R.
author_facet Plens-Gałąska, Martyna
Woźniak, Tomasz
Wesoły, Joanna
Bluyssen, Hans A. R.
author_sort Plens-Gałąska, Martyna
collection PubMed
description The abnormal activation of signal transducer and activator of transcription (STAT) protein family is recognized as cause or driving force behind multiple diseases progression. Therefore, searching for potential treatment strategy is pursued by multiple scientific groups. We consider that providing comprehensive, integrated and unified dataset for STAT inhibitory compounds may serve as important tool for other researchers. We developed SINBAD (STAT INhbitor Biology And Drug-ability) in response to our experience with inhibitory compound research, knowing that gathering detailed information is crucial for effective experiment design and also for finding potential solutions in case of obtaining inconclusive results. SINBAD is a curated database of STAT inhibitors which have been published and described in scientific articles providing prove of their inhibitory properties. It is a tool allowing easy analysis of experimental conditions and provides detailed information about known STAT inhibitory compounds.
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spelling pubmed-89714792022-04-20 SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications Plens-Gałąska, Martyna Woźniak, Tomasz Wesoły, Joanna Bluyssen, Hans A. R. Sci Data Data Descriptor The abnormal activation of signal transducer and activator of transcription (STAT) protein family is recognized as cause or driving force behind multiple diseases progression. Therefore, searching for potential treatment strategy is pursued by multiple scientific groups. We consider that providing comprehensive, integrated and unified dataset for STAT inhibitory compounds may serve as important tool for other researchers. We developed SINBAD (STAT INhbitor Biology And Drug-ability) in response to our experience with inhibitory compound research, knowing that gathering detailed information is crucial for effective experiment design and also for finding potential solutions in case of obtaining inconclusive results. SINBAD is a curated database of STAT inhibitors which have been published and described in scientific articles providing prove of their inhibitory properties. It is a tool allowing easy analysis of experimental conditions and provides detailed information about known STAT inhibitory compounds. Nature Publishing Group UK 2022-03-31 /pmc/articles/PMC8971479/ /pubmed/35361787 http://dx.doi.org/10.1038/s41597-022-01243-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Data Descriptor
Plens-Gałąska, Martyna
Woźniak, Tomasz
Wesoły, Joanna
Bluyssen, Hans A. R.
SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title_full SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title_fullStr SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title_full_unstemmed SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title_short SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications
title_sort sinbad, structural, experimental and clinical characterization of stat inhibitors and their potential applications
topic Data Descriptor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971479/
https://www.ncbi.nlm.nih.gov/pubmed/35361787
http://dx.doi.org/10.1038/s41597-022-01243-3
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