Nuclear Aurora kinase A switches m(6)A reader YTHDC1 to enhance an oncogenic RNA splicing of tumor suppressor RBM4

Aberrant RNA splicing produces alternative isoforms of genes to facilitate tumor progression, yet how this process is regulated by oncogenic signal remains largely unknown. Here, we unveil that non-canonical activation of nuclear AURKA promotes an oncogenic RNA splicing of tumor suppressor RBM4 dire...

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Detalles Bibliográficos
Autores principales: Li, SiSi, Qi, YangFan, Yu, JiaChuan, Hao, YuChao, He, Bin, Zhang, MengJuan, Dai, ZhenWei, Jiang, TongHui, Li, SuYi, Huang, Fang, Chen, Ning, Wang, Jing, Yang, MengYing, Liang, DaPeng, An, Fan, Zhao, JinYao, Fan, WenJun, Pan, YuJia, Deng, ZiQian, Luo, YuanYuan, Guo, Tao, Peng, Fei, Hou, ZhiJie, Wang, ChunLi, Zheng, FeiMeng, Xu, LingZhi, Xu, Jie, Wen, QingPing, Jin, BiLian, Wang, Yang, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971511/
https://www.ncbi.nlm.nih.gov/pubmed/35361747
http://dx.doi.org/10.1038/s41392-022-00905-3

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