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The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe

Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infections in this country based on Bayesian phylogeographic appro...

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Autores principales: Perez, Lester J, Orf, Gregory S, Berg, Michael G, Rodgers, Mary A, Meyer, Todd V, Mohaimani, Aurash, Olivo, Ana, Harris, Barbara, Mowerman, Illya, Padane, Abdou, Dela-del Lawson, Agbogbenkou Tevi, Mboup, Aminata, Mbow, Moustapha, Leye, Nafissatou, Touré-Kane, Ndeye Coumba, Ahouidi, Ambroise D, Cloherty, Gavin A, Mboup, Souleymane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971539/
https://www.ncbi.nlm.nih.gov/pubmed/35371561
http://dx.doi.org/10.1093/ve/veac025
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author Perez, Lester J
Orf, Gregory S
Berg, Michael G
Rodgers, Mary A
Meyer, Todd V
Mohaimani, Aurash
Olivo, Ana
Harris, Barbara
Mowerman, Illya
Padane, Abdou
Dela-del Lawson, Agbogbenkou Tevi
Mboup, Aminata
Mbow, Moustapha
Leye, Nafissatou
Touré-Kane, Ndeye Coumba
Ahouidi, Ambroise D
Cloherty, Gavin A
Mboup, Souleymane
author_facet Perez, Lester J
Orf, Gregory S
Berg, Michael G
Rodgers, Mary A
Meyer, Todd V
Mohaimani, Aurash
Olivo, Ana
Harris, Barbara
Mowerman, Illya
Padane, Abdou
Dela-del Lawson, Agbogbenkou Tevi
Mboup, Aminata
Mbow, Moustapha
Leye, Nafissatou
Touré-Kane, Ndeye Coumba
Ahouidi, Ambroise D
Cloherty, Gavin A
Mboup, Souleymane
author_sort Perez, Lester J
collection PubMed
description Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infections in this country based on Bayesian phylogeographic approaches. Whereas the first wave in mid-2020 was characterized by a significant diversification of lineages and predominance of B.1.416, the second wave in late 2020 was composed primarily of B.1.1.420. Our results indicate that B.1.416 originated in Senegal and was exported mainly to Europe. In contrast, B.1.1.420 was introduced from Italy, gained fitness in Senegal, and then spread worldwide. Since both B.1.416 and B.1.1.420 lineages carry several positive selected mutations in the spike and nucleocapsid genes, each of which may explain their local dominance, their mutation profiles should be carefully monitored. As the pandemic continues to evolve, molecular surveillance in all regions of Africa will play a key role in stemming its spread.
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spelling pubmed-89715392022-04-01 The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe Perez, Lester J Orf, Gregory S Berg, Michael G Rodgers, Mary A Meyer, Todd V Mohaimani, Aurash Olivo, Ana Harris, Barbara Mowerman, Illya Padane, Abdou Dela-del Lawson, Agbogbenkou Tevi Mboup, Aminata Mbow, Moustapha Leye, Nafissatou Touré-Kane, Ndeye Coumba Ahouidi, Ambroise D Cloherty, Gavin A Mboup, Souleymane Virus Evol Research Article Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infections in this country based on Bayesian phylogeographic approaches. Whereas the first wave in mid-2020 was characterized by a significant diversification of lineages and predominance of B.1.416, the second wave in late 2020 was composed primarily of B.1.1.420. Our results indicate that B.1.416 originated in Senegal and was exported mainly to Europe. In contrast, B.1.1.420 was introduced from Italy, gained fitness in Senegal, and then spread worldwide. Since both B.1.416 and B.1.1.420 lineages carry several positive selected mutations in the spike and nucleocapsid genes, each of which may explain their local dominance, their mutation profiles should be carefully monitored. As the pandemic continues to evolve, molecular surveillance in all regions of Africa will play a key role in stemming its spread. Oxford University Press 2022-03-21 /pmc/articles/PMC8971539/ /pubmed/35371561 http://dx.doi.org/10.1093/ve/veac025 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Perez, Lester J
Orf, Gregory S
Berg, Michael G
Rodgers, Mary A
Meyer, Todd V
Mohaimani, Aurash
Olivo, Ana
Harris, Barbara
Mowerman, Illya
Padane, Abdou
Dela-del Lawson, Agbogbenkou Tevi
Mboup, Aminata
Mbow, Moustapha
Leye, Nafissatou
Touré-Kane, Ndeye Coumba
Ahouidi, Ambroise D
Cloherty, Gavin A
Mboup, Souleymane
The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title_full The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title_fullStr The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title_full_unstemmed The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title_short The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe
title_sort early sars-cov-2 epidemic in senegal was driven by the local emergence of b.1.416 and the introduction of b.1.1.420 from europe
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971539/
https://www.ncbi.nlm.nih.gov/pubmed/35371561
http://dx.doi.org/10.1093/ve/veac025
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