Cargando…
High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults
BACKGROUND: Sarcopenia is an age-related clinical condition and associated with an increased risk of adverse outcomes. However, to date, there is no global standard for the diagnosis of sarcopenia, and fewer serum biomarkers have been suggested for the diagnosis of sarcopenia. It is, thus, important...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971564/ https://www.ncbi.nlm.nih.gov/pubmed/35370985 http://dx.doi.org/10.3389/fendo.2022.843610 |
_version_ | 1784679662012596224 |
---|---|
author | He, Yong Ding, Fing Yin, Mengting Zhang, He Hou, Lisha Cui, Tao Xu, Jinfeng Yue, Jirong Zheng, Qin |
author_facet | He, Yong Ding, Fing Yin, Mengting Zhang, He Hou, Lisha Cui, Tao Xu, Jinfeng Yue, Jirong Zheng, Qin |
author_sort | He, Yong |
collection | PubMed |
description | BACKGROUND: Sarcopenia is an age-related clinical condition and associated with an increased risk of adverse outcomes. However, to date, there is no global standard for the diagnosis of sarcopenia, and fewer serum biomarkers have been suggested for the diagnosis of sarcopenia. It is, thus, important that sarcopenia-related serological diagnostic markers be explored. The present study was based on the Asian Working Group on Sarcopenia 2019 (AWGS 2019) criteria to assess whether aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and fasting insulin*prealbumin (INS*PA) product are diagnostic markers associated with sarcopenia in various ethnic groups in western China. METHODS: This cross-sectional study included 4,099 adults (1,471 men and 2,628 women) from the West China Health and Aging Trend (WCHAT) study. The value of serum biomarkers was based on laboratory data. The accompanying metabolic disorders and the associated parameters were evaluated. Logistic regression analysis was used to explore the association between markers and sarcopenia. Receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic efficacy of the test in differentiating sarcopenia. RESULTS: Binary regression analysis showed that high serum AST/ALT (OR = 2.247) and adrenal cortisol (PTC, OR = 1.511), low serum INS*PA (OR = 2.970), free triiodothyronine (FT3, OR = 1.313), 25-OH-VitD (VitD, in male participants, OR = 1.817), and diastolic blood pressure (DBP, in female subjects, OR = 1.250) were independent risk factors for sarcopenia (P < 0.05). AST/ALT and INS*PA were not affected by metabolic factors and had better diagnostic efficacy for sarcopenia. The AUC of the INS*PA was the highest (0.705, 0.706, and 0.701, respectively, P < 0.05), followed by that of the AST/ALT (0.680, 0.675, and 0.695, respectively, P < 0.05). The AUC of the AST/ALT/(INS*PA)*10,000 used to diagnose sarcopenia was 0.727. CONCLUSION: Among middle-aged and older adults of multiple ethnicities in western China, we found that higher AST/ALT and lower INS*PA levels are associated with an increased prevalence of sarcopenia. Since these serum biomarkers are inexpensive and can be obtained easily from biochemical routine, regular follow-up of AST/ALT and INS*PA may be an effective strategy in sarcopenia screening and management. |
format | Online Article Text |
id | pubmed-8971564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89715642022-04-02 High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults He, Yong Ding, Fing Yin, Mengting Zhang, He Hou, Lisha Cui, Tao Xu, Jinfeng Yue, Jirong Zheng, Qin Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Sarcopenia is an age-related clinical condition and associated with an increased risk of adverse outcomes. However, to date, there is no global standard for the diagnosis of sarcopenia, and fewer serum biomarkers have been suggested for the diagnosis of sarcopenia. It is, thus, important that sarcopenia-related serological diagnostic markers be explored. The present study was based on the Asian Working Group on Sarcopenia 2019 (AWGS 2019) criteria to assess whether aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and fasting insulin*prealbumin (INS*PA) product are diagnostic markers associated with sarcopenia in various ethnic groups in western China. METHODS: This cross-sectional study included 4,099 adults (1,471 men and 2,628 women) from the West China Health and Aging Trend (WCHAT) study. The value of serum biomarkers was based on laboratory data. The accompanying metabolic disorders and the associated parameters were evaluated. Logistic regression analysis was used to explore the association between markers and sarcopenia. Receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic efficacy of the test in differentiating sarcopenia. RESULTS: Binary regression analysis showed that high serum AST/ALT (OR = 2.247) and adrenal cortisol (PTC, OR = 1.511), low serum INS*PA (OR = 2.970), free triiodothyronine (FT3, OR = 1.313), 25-OH-VitD (VitD, in male participants, OR = 1.817), and diastolic blood pressure (DBP, in female subjects, OR = 1.250) were independent risk factors for sarcopenia (P < 0.05). AST/ALT and INS*PA were not affected by metabolic factors and had better diagnostic efficacy for sarcopenia. The AUC of the INS*PA was the highest (0.705, 0.706, and 0.701, respectively, P < 0.05), followed by that of the AST/ALT (0.680, 0.675, and 0.695, respectively, P < 0.05). The AUC of the AST/ALT/(INS*PA)*10,000 used to diagnose sarcopenia was 0.727. CONCLUSION: Among middle-aged and older adults of multiple ethnicities in western China, we found that higher AST/ALT and lower INS*PA levels are associated with an increased prevalence of sarcopenia. Since these serum biomarkers are inexpensive and can be obtained easily from biochemical routine, regular follow-up of AST/ALT and INS*PA may be an effective strategy in sarcopenia screening and management. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8971564/ /pubmed/35370985 http://dx.doi.org/10.3389/fendo.2022.843610 Text en Copyright © 2022 He, Ding, Yin, Zhang, Hou, Cui, Xu, Yue and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology He, Yong Ding, Fing Yin, Mengting Zhang, He Hou, Lisha Cui, Tao Xu, Jinfeng Yue, Jirong Zheng, Qin High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title | High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title_full | High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title_fullStr | High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title_full_unstemmed | High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title_short | High Serum AST/ALT Ratio and Low Serum INS*PA Product Are Risk Factors and Can Diagnose Sarcopenia in Middle-Aged and Older Adults |
title_sort | high serum ast/alt ratio and low serum ins*pa product are risk factors and can diagnose sarcopenia in middle-aged and older adults |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971564/ https://www.ncbi.nlm.nih.gov/pubmed/35370985 http://dx.doi.org/10.3389/fendo.2022.843610 |
work_keys_str_mv | AT heyong highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT dingfing highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT yinmengting highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT zhanghe highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT houlisha highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT cuitao highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT xujinfeng highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT yuejirong highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults AT zhengqin highserumastaltratioandlowseruminspaproductareriskfactorsandcandiagnosesarcopeniainmiddleagedandolderadults |