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Flexible polymeric patch based nanotherapeutics against non-cancer therapy

Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance, superior biocompatibility and biodegradation, as well as high loading capability and permeability of drug. Such polymeric patches are classi...

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Autores principales: Zhu, Houjuan, Mah Jian Qiang, Justin, Wang, Chen Gang, Chan, Chui Yu, Zhu, Qiang, Ye, Enyi, Li, Zibiao, Loh, Xian Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971585/
https://www.ncbi.nlm.nih.gov/pubmed/35415299
http://dx.doi.org/10.1016/j.bioactmat.2022.03.034
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author Zhu, Houjuan
Mah Jian Qiang, Justin
Wang, Chen Gang
Chan, Chui Yu
Zhu, Qiang
Ye, Enyi
Li, Zibiao
Loh, Xian Jun
author_facet Zhu, Houjuan
Mah Jian Qiang, Justin
Wang, Chen Gang
Chan, Chui Yu
Zhu, Qiang
Ye, Enyi
Li, Zibiao
Loh, Xian Jun
author_sort Zhu, Houjuan
collection PubMed
description Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance, superior biocompatibility and biodegradation, as well as high loading capability and permeability of drug. Such polymeric patches are classified into microneedles (MNs), hydrogel, microcapsule, microsphere and fiber depending on the formed morphology. The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity, promoting on-demand and regulated drug administration, thus providing the great potential to their clinic translation. In this review, the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed. The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed, including diabetes therapy, wound healing, dermatological disease therapy, bone regeneration, cardiac repair, hair repair, obesity therapy and some immune disease therapy. Alternatively, the limitations, latest challenges and future perspectives of such biomedical therapeutic devices are addressed.
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spelling pubmed-89715852022-04-11 Flexible polymeric patch based nanotherapeutics against non-cancer therapy Zhu, Houjuan Mah Jian Qiang, Justin Wang, Chen Gang Chan, Chui Yu Zhu, Qiang Ye, Enyi Li, Zibiao Loh, Xian Jun Bioact Mater Review Article Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance, superior biocompatibility and biodegradation, as well as high loading capability and permeability of drug. Such polymeric patches are classified into microneedles (MNs), hydrogel, microcapsule, microsphere and fiber depending on the formed morphology. The combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity, promoting on-demand and regulated drug administration, thus providing the great potential to their clinic translation. In this review, the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further discussed. The applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed, including diabetes therapy, wound healing, dermatological disease therapy, bone regeneration, cardiac repair, hair repair, obesity therapy and some immune disease therapy. Alternatively, the limitations, latest challenges and future perspectives of such biomedical therapeutic devices are addressed. KeAi Publishing 2022-03-30 /pmc/articles/PMC8971585/ /pubmed/35415299 http://dx.doi.org/10.1016/j.bioactmat.2022.03.034 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zhu, Houjuan
Mah Jian Qiang, Justin
Wang, Chen Gang
Chan, Chui Yu
Zhu, Qiang
Ye, Enyi
Li, Zibiao
Loh, Xian Jun
Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title_full Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title_fullStr Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title_full_unstemmed Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title_short Flexible polymeric patch based nanotherapeutics against non-cancer therapy
title_sort flexible polymeric patch based nanotherapeutics against non-cancer therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971585/
https://www.ncbi.nlm.nih.gov/pubmed/35415299
http://dx.doi.org/10.1016/j.bioactmat.2022.03.034
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