Autophagy and Skin Diseases

Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiol...

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Autores principales: Klapan, Kim, Simon, Dagmar, Karaulov, Alexander, Gomzikova, Marina, Rizvanov, Albert, Yousefi, Shida, Simon, Hans-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971629/
https://www.ncbi.nlm.nih.gov/pubmed/35370701
http://dx.doi.org/10.3389/fphar.2022.844756
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author Klapan, Kim
Simon, Dagmar
Karaulov, Alexander
Gomzikova, Marina
Rizvanov, Albert
Yousefi, Shida
Simon, Hans-Uwe
author_facet Klapan, Kim
Simon, Dagmar
Karaulov, Alexander
Gomzikova, Marina
Rizvanov, Albert
Yousefi, Shida
Simon, Hans-Uwe
author_sort Klapan, Kim
collection PubMed
description Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy have been implicated in the pathophysiology of a variety of human diseases. The new line of evidence suggests that autophagy is inextricably linked to skin disorders. This review summarizes the principles behind autophagy and highlights current findings of autophagy’s role in skin disorders and strategies for therapeutic modulation.
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spelling pubmed-89716292022-04-02 Autophagy and Skin Diseases Klapan, Kim Simon, Dagmar Karaulov, Alexander Gomzikova, Marina Rizvanov, Albert Yousefi, Shida Simon, Hans-Uwe Front Pharmacol Pharmacology Autophagy is a highly conserved lysosomal degradation system that involves the creation of autophagosomes, which eventually fuse with lysosomes and breakdown misfolded proteins and damaged organelles with their enzymes. Autophagy is widely known for its function in cellular homeostasis under physiological and pathological settings. Defects in autophagy have been implicated in the pathophysiology of a variety of human diseases. The new line of evidence suggests that autophagy is inextricably linked to skin disorders. This review summarizes the principles behind autophagy and highlights current findings of autophagy’s role in skin disorders and strategies for therapeutic modulation. Frontiers Media S.A. 2022-02-18 /pmc/articles/PMC8971629/ /pubmed/35370701 http://dx.doi.org/10.3389/fphar.2022.844756 Text en Copyright © 2022 Klapan, Simon, Karaulov, Gomzikova, Rizvanov, Yousefi and Simon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Klapan, Kim
Simon, Dagmar
Karaulov, Alexander
Gomzikova, Marina
Rizvanov, Albert
Yousefi, Shida
Simon, Hans-Uwe
Autophagy and Skin Diseases
title Autophagy and Skin Diseases
title_full Autophagy and Skin Diseases
title_fullStr Autophagy and Skin Diseases
title_full_unstemmed Autophagy and Skin Diseases
title_short Autophagy and Skin Diseases
title_sort autophagy and skin diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971629/
https://www.ncbi.nlm.nih.gov/pubmed/35370701
http://dx.doi.org/10.3389/fphar.2022.844756
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AT gomzikovamarina autophagyandskindiseases
AT rizvanovalbert autophagyandskindiseases
AT yousefishida autophagyandskindiseases
AT simonhansuwe autophagyandskindiseases

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