Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells

Aconitine is one of the main bioactive and toxic ingredients of Aconitum species. Increasingly, aconitine has been reported to induce neurotoxicity. However, whether aconitine has effects on the dopaminergic nervous system remains unclear. In this study, zebrafish embryos at 6-days postfertilization...

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Detalles Bibliográficos
Autores principales: Zhou, Jie, Peng, Cheng, Li, Qiuju, Yan, Xiaoyu, Yang, Liang, Li, Mengting, Cao, Xiaoyu, Xie, Xiaofang, Chen, Dayi, Rao, Chaolong, Huang, Sizhou, Peng, Fu, Pan, Xiaoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971779/
https://www.ncbi.nlm.nih.gov/pubmed/35370746
http://dx.doi.org/10.3389/fphar.2022.837810

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