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Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

BACKGROUND: The majority of colorectal carcinomas (CRCs) are insensitive to programmed death protein-1/programmed death-ligand 1 (anti-PD-1/PD-L1) immune checkpoint inhibitor (ICI) antibodies. While there are many causes for ICI insensitivity, recent studies suggest that suppression of innate immune...

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Detalles Bibliográficos
Autores principales:	Hwang, Bin-Jin, Tsao, Li-Chung, Acharya, Chaitanya R, Trotter, Timothy, Agarwal, Pankaj, Wei, Junping, Wang, Tao, Yang, Xiao-Yi, Lei, Gangjun, Osada, Takuya, Lyerly, Herbert Kim, Morse, Michael A, Hartman, Zachary Conrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971789/ https://www.ncbi.nlm.nih.gov/pubmed/35361727 http://dx.doi.org/10.1136/jitc-2021-003721

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