Cargando…

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

Classical malaria parasite genetic crosses involve isolation, genotyping, and phenotyping of progeny parasites, which is time consuming and laborious. We tested a rapid alternative approach—bulk segregant analysis (BSA)—that utilizes sequencing of bulk progeny populations with and without drug selec...

Descripción completa

Detalles Bibliográficos
Autores principales: Brenneman, Katelyn Vendrely, Li, Xue, Kumar, Sudhir, Delgado, Elizabeth, Checkley, Lisa A., Shoue, Douglas A., Reyes, Ann, Abatiyow, Biley A., Haile, Meseret T., Tripura, Rupam, Peto, Tom, Lek, Dysoley, Button-Simons, Katrina A., Kappe, Stefan H.I., Dhorda, Mehul, Nosten, François, Nkhoma, Standwell C., Cheeseman, Ian H., Vaughan, Ashley M., Ferdig, Michael T., Anderson, Tim J.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8971943/
https://www.ncbi.nlm.nih.gov/pubmed/35372813
http://dx.doi.org/10.1016/j.isci.2022.104095