Somatic activating BRAF variants cause isolated lymphatic malformations

Somatic activating variants in PIK3CA, the gene that encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), have been previously detected in ∼80% of lymphatic malformations (LMs).(1)(,)(2) We report the presence of somatic activating variants in BRAF in individuals with LMs tha...

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Detalles Bibliográficos
Autores principales: Zenner, Kaitlyn, Jensen, Dana M., Dmyterko, Victoria, Shivaram, Giridhar M., Myers, Candace T., Paschal, Cate R., Rudzinski, Erin R., Pham, Minh-Hang M., Cheng, V. Chi, Manning, Scott C., Bly, Randall A., Ganti, Sheila, Perkins, Jonathan A., Bennett, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972000/
https://www.ncbi.nlm.nih.gov/pubmed/35373151
http://dx.doi.org/10.1016/j.xhgg.2022.100101

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