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Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration

Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular processes and pathologies, either within lysosomes, upon sec...

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Detalles Bibliográficos
Autores principales: Kos, Janko, Mitrović, Ana, Perišić Nanut, Milica, Pišlar, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972049/
https://www.ncbi.nlm.nih.gov/pubmed/35067006
http://dx.doi.org/10.1002/2211-5463.13372
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author Kos, Janko
Mitrović, Ana
Perišić Nanut, Milica
Pišlar, Anja
author_facet Kos, Janko
Mitrović, Ana
Perišić Nanut, Milica
Pišlar, Anja
author_sort Kos, Janko
collection PubMed
description Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular processes and pathologies, either within lysosomes, upon secretion into the cell cytoplasm or extracellular space, or bound to the plasma membrane. In cancer, lysosomal peptidases are generally associated with disease progression, as they participate in crucial processes leading to changes in cell morphology, signaling, migration, and invasion, and finally metastasis. However, they can also enhance the mechanisms resulting in cancer regression, such as apoptosis of tumor cells or antitumor immune responses. Lysosomal peptidases have also been identified as hallmarks of aging and neurodegeneration, playing roles in oxidative stress, mitochondrial dysfunction, abnormal intercellular communication, dysregulated trafficking, and the deposition of protein aggregates in neuronal cells. Furthermore, deficiencies in lysosomal peptidases may result in other pathological states, such as lysosomal storage disease. The aim of this review was to highlight the role of lysosomal peptidases in particular pathological processes of cancer and neurodegeneration and to address the potential of lysosomal peptidases in diagnosing and treating patients.
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spelling pubmed-89720492022-04-05 Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration Kos, Janko Mitrović, Ana Perišić Nanut, Milica Pišlar, Anja FEBS Open Bio Reviews Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular processes and pathologies, either within lysosomes, upon secretion into the cell cytoplasm or extracellular space, or bound to the plasma membrane. In cancer, lysosomal peptidases are generally associated with disease progression, as they participate in crucial processes leading to changes in cell morphology, signaling, migration, and invasion, and finally metastasis. However, they can also enhance the mechanisms resulting in cancer regression, such as apoptosis of tumor cells or antitumor immune responses. Lysosomal peptidases have also been identified as hallmarks of aging and neurodegeneration, playing roles in oxidative stress, mitochondrial dysfunction, abnormal intercellular communication, dysregulated trafficking, and the deposition of protein aggregates in neuronal cells. Furthermore, deficiencies in lysosomal peptidases may result in other pathological states, such as lysosomal storage disease. The aim of this review was to highlight the role of lysosomal peptidases in particular pathological processes of cancer and neurodegeneration and to address the potential of lysosomal peptidases in diagnosing and treating patients. John Wiley and Sons Inc. 2022-02-03 /pmc/articles/PMC8972049/ /pubmed/35067006 http://dx.doi.org/10.1002/2211-5463.13372 Text en © 2022 The Authors. FEBS Open Bio published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Kos, Janko
Mitrović, Ana
Perišić Nanut, Milica
Pišlar, Anja
Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title_full Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title_fullStr Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title_full_unstemmed Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title_short Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
title_sort lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972049/
https://www.ncbi.nlm.nih.gov/pubmed/35067006
http://dx.doi.org/10.1002/2211-5463.13372
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