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The translational landscape as regulated by the RNA helicase DDX3

Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed...

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Autores principales: Park, Joon Tae, Oh, Sekyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972136/
https://www.ncbi.nlm.nih.gov/pubmed/35236544
http://dx.doi.org/10.5483/BMBRep.2022.55.3.188
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author Park, Joon Tae
Oh, Sekyung
author_facet Park, Joon Tae
Oh, Sekyung
author_sort Park, Joon Tae
collection PubMed
description Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell.
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spelling pubmed-89721362022-04-06 The translational landscape as regulated by the RNA helicase DDX3 Park, Joon Tae Oh, Sekyung BMB Rep Invited Mini Review Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell. Korean Society for Biochemistry and Molecular Biology 2022-03-31 2022-03-31 /pmc/articles/PMC8972136/ /pubmed/35236544 http://dx.doi.org/10.5483/BMBRep.2022.55.3.188 Text en Copyright © 2022 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Park, Joon Tae
Oh, Sekyung
The translational landscape as regulated by the RNA helicase DDX3
title The translational landscape as regulated by the RNA helicase DDX3
title_full The translational landscape as regulated by the RNA helicase DDX3
title_fullStr The translational landscape as regulated by the RNA helicase DDX3
title_full_unstemmed The translational landscape as regulated by the RNA helicase DDX3
title_short The translational landscape as regulated by the RNA helicase DDX3
title_sort translational landscape as regulated by the rna helicase ddx3
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972136/
https://www.ncbi.nlm.nih.gov/pubmed/35236544
http://dx.doi.org/10.5483/BMBRep.2022.55.3.188
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