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The translational landscape as regulated by the RNA helicase DDX3
Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972136/ https://www.ncbi.nlm.nih.gov/pubmed/35236544 http://dx.doi.org/10.5483/BMBRep.2022.55.3.188 |
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author | Park, Joon Tae Oh, Sekyung |
author_facet | Park, Joon Tae Oh, Sekyung |
author_sort | Park, Joon Tae |
collection | PubMed |
description | Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell. |
format | Online Article Text |
id | pubmed-8972136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-89721362022-04-06 The translational landscape as regulated by the RNA helicase DDX3 Park, Joon Tae Oh, Sekyung BMB Rep Invited Mini Review Continuously renewing the proteome, translation is exquisitely controlled by a number of dedicated factors that interact with the ribosome. The RNA helicase DDX3 belonging to the DEAD box family has emerged as one of the critical regulators of translation, the failure of which is frequently observed in a wide range of proliferative, degenerative, and infectious diseases in humans. DDX3 unwinds double-stranded RNA molecules with coupled ATP hydrolysis and thereby remodels complex RNA structures present in various protein-coding and noncoding RNAs. By interacting with specific features on messenger RNAs (mRNAs) and 18S ribosomal RNA (rRNA), DDX3 facilitates translation, while repressing it under certain conditions. We review recent findings underlying these properties of DDX3 in diverse modes of translation, such as cap-dependent and cap-independent translation initiation, usage of upstream open reading frames, and stress-induced ribonucleoprotein granule formation. We further discuss how disease-associated DDX3 variants alter the translation landscape in the cell. Korean Society for Biochemistry and Molecular Biology 2022-03-31 2022-03-31 /pmc/articles/PMC8972136/ /pubmed/35236544 http://dx.doi.org/10.5483/BMBRep.2022.55.3.188 Text en Copyright © 2022 by the The Korean Society for Biochemistry and Molecular Biology https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Park, Joon Tae Oh, Sekyung The translational landscape as regulated by the RNA helicase DDX3 |
title | The translational landscape as regulated by the RNA helicase DDX3 |
title_full | The translational landscape as regulated by the RNA helicase DDX3 |
title_fullStr | The translational landscape as regulated by the RNA helicase DDX3 |
title_full_unstemmed | The translational landscape as regulated by the RNA helicase DDX3 |
title_short | The translational landscape as regulated by the RNA helicase DDX3 |
title_sort | translational landscape as regulated by the rna helicase ddx3 |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972136/ https://www.ncbi.nlm.nih.gov/pubmed/35236544 http://dx.doi.org/10.5483/BMBRep.2022.55.3.188 |
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