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The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition
Surgical patients with coronavirus disease 2019 (COVID-19) are vulnerable to increased perioperative complications and postoperative mortality, independent of the risk for contracting COVID-19 pneumonia after endotracheal intubation for general anesthesia. The presumed root cause of postoperative in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972719/ https://www.ncbi.nlm.nih.gov/pubmed/35365199 http://dx.doi.org/10.1186/s13037-022-00323-y |
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author | Stahel, Vincent P. Blum, Samson D. Anand, Pratibha |
author_facet | Stahel, Vincent P. Blum, Samson D. Anand, Pratibha |
author_sort | Stahel, Vincent P. |
collection | PubMed |
description | Surgical patients with coronavirus disease 2019 (COVID-19) are vulnerable to increased perioperative complications and postoperative mortality, independent of the risk for contracting COVID-19 pneumonia after endotracheal intubation for general anesthesia. The presumed root cause of postoperative infections, microvascular soft tissue injuries and thromboembolic complications is largely attributed to the profound immune dysfunction induced by COVID-19 as a result of complement activation and the “cytokine storm”. The empirical therapy with anti-inflammatory agents has been shown to attenuate some of the adverse effects of systemic hyperinflammation in COVID-19 patients. In addition, the proactive concept of “immunonutrition” may represent a new promising avenue for mitigating the complex immune dysregulation in COVID-19 and thereby reduce the rates of surgical complications and postoperative mortality. This letter provides a narrative summary of the current state-of-the-art in the field of immunonutrition as it pertains to surgical patient safety in COVID-19 patients. |
format | Online Article Text |
id | pubmed-8972719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-89727192022-04-01 The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition Stahel, Vincent P. Blum, Samson D. Anand, Pratibha Patient Saf Surg Letter to the Editor Surgical patients with coronavirus disease 2019 (COVID-19) are vulnerable to increased perioperative complications and postoperative mortality, independent of the risk for contracting COVID-19 pneumonia after endotracheal intubation for general anesthesia. The presumed root cause of postoperative infections, microvascular soft tissue injuries and thromboembolic complications is largely attributed to the profound immune dysfunction induced by COVID-19 as a result of complement activation and the “cytokine storm”. The empirical therapy with anti-inflammatory agents has been shown to attenuate some of the adverse effects of systemic hyperinflammation in COVID-19 patients. In addition, the proactive concept of “immunonutrition” may represent a new promising avenue for mitigating the complex immune dysregulation in COVID-19 and thereby reduce the rates of surgical complications and postoperative mortality. This letter provides a narrative summary of the current state-of-the-art in the field of immunonutrition as it pertains to surgical patient safety in COVID-19 patients. BioMed Central 2022-04-01 /pmc/articles/PMC8972719/ /pubmed/35365199 http://dx.doi.org/10.1186/s13037-022-00323-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Letter to the Editor Stahel, Vincent P. Blum, Samson D. Anand, Pratibha The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title | The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title_full | The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title_fullStr | The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title_full_unstemmed | The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title_short | The impact of immune dysfunction on perioperative complications in surgical COVID-19 patients: an imperative for early immunonutrition |
title_sort | impact of immune dysfunction on perioperative complications in surgical covid-19 patients: an imperative for early immunonutrition |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972719/ https://www.ncbi.nlm.nih.gov/pubmed/35365199 http://dx.doi.org/10.1186/s13037-022-00323-y |
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