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Evaluation of Oxidative Stress in Ectopic Pregnancies

PURPOSE: The aim of the study is to show the relationship between oxidative stress and ectopic pregnancy. MATERIALS AND METHODS: A total of 62 patients, 31 in the ectopic pregnancy group (study group) and 31 in the first-trimester pregnancy (control group) were included in the study. Patients betwee...

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Autores principales: Üreyen Özdemir, Eda, Yalçın Bahat, Pınar, Topbaş Selçuki, Nura Fitnat, Çakmak, Kübra, Çakmak, Fatih, Neşelioğlu, Salim, Erel, Özcan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972882/
https://www.ncbi.nlm.nih.gov/pubmed/35315421
http://dx.doi.org/10.23750/abm.v93i1.11097
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author Üreyen Özdemir, Eda
Yalçın Bahat, Pınar
Topbaş Selçuki, Nura Fitnat
Çakmak, Kübra
Çakmak, Fatih
Neşelioğlu, Salim
Erel, Özcan
author_facet Üreyen Özdemir, Eda
Yalçın Bahat, Pınar
Topbaş Selçuki, Nura Fitnat
Çakmak, Kübra
Çakmak, Fatih
Neşelioğlu, Salim
Erel, Özcan
author_sort Üreyen Özdemir, Eda
collection PubMed
description PURPOSE: The aim of the study is to show the relationship between oxidative stress and ectopic pregnancy. MATERIALS AND METHODS: A total of 62 patients, 31 in the ectopic pregnancy group (study group) and 31 in the first-trimester pregnancy (control group) were included in the study. Patients between 18-45 years of age who had tubal ectopic pregnancy diagnosed by transvaginal ultrasonography and serum β-HCG values were included in the study group. Serum thiol- disulfide hemostasis were measured from venous blood. RESULTS: Between the control group and the ectopic pregnant group; there was no statistically significant difference in terms of age, total thiol, albumin, disulfide, index 1 (disulfide / total thiol), index 2 (disulfide / native thiol), and index 3 levels (p> 0.05). The area under the ROC curve for native thiol measurements was statistically significant in distinguishing the control group and the ectopic pregnant group [AUC = 0.657, 95% CI: 0.521-0.793, p = 0.034]. CONCLUSION: This study shows that ectopic pregnancies may be associated with the presence of high oxidative stress. Especially in early stage suspected patients, demonstrating the presence of oxidative stress together with serial β-HCG follow-up may be helpful in diagnosis. (www.actabiomedica.it)
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spelling pubmed-89728822022-04-15 Evaluation of Oxidative Stress in Ectopic Pregnancies Üreyen Özdemir, Eda Yalçın Bahat, Pınar Topbaş Selçuki, Nura Fitnat Çakmak, Kübra Çakmak, Fatih Neşelioğlu, Salim Erel, Özcan Acta Biomed Original Article PURPOSE: The aim of the study is to show the relationship between oxidative stress and ectopic pregnancy. MATERIALS AND METHODS: A total of 62 patients, 31 in the ectopic pregnancy group (study group) and 31 in the first-trimester pregnancy (control group) were included in the study. Patients between 18-45 years of age who had tubal ectopic pregnancy diagnosed by transvaginal ultrasonography and serum β-HCG values were included in the study group. Serum thiol- disulfide hemostasis were measured from venous blood. RESULTS: Between the control group and the ectopic pregnant group; there was no statistically significant difference in terms of age, total thiol, albumin, disulfide, index 1 (disulfide / total thiol), index 2 (disulfide / native thiol), and index 3 levels (p> 0.05). The area under the ROC curve for native thiol measurements was statistically significant in distinguishing the control group and the ectopic pregnant group [AUC = 0.657, 95% CI: 0.521-0.793, p = 0.034]. CONCLUSION: This study shows that ectopic pregnancies may be associated with the presence of high oxidative stress. Especially in early stage suspected patients, demonstrating the presence of oxidative stress together with serial β-HCG follow-up may be helpful in diagnosis. (www.actabiomedica.it) Mattioli 1885 2022 2022-03-14 /pmc/articles/PMC8972882/ /pubmed/35315421 http://dx.doi.org/10.23750/abm.v93i1.11097 Text en Copyright: © 2021 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Original Article
Üreyen Özdemir, Eda
Yalçın Bahat, Pınar
Topbaş Selçuki, Nura Fitnat
Çakmak, Kübra
Çakmak, Fatih
Neşelioğlu, Salim
Erel, Özcan
Evaluation of Oxidative Stress in Ectopic Pregnancies
title Evaluation of Oxidative Stress in Ectopic Pregnancies
title_full Evaluation of Oxidative Stress in Ectopic Pregnancies
title_fullStr Evaluation of Oxidative Stress in Ectopic Pregnancies
title_full_unstemmed Evaluation of Oxidative Stress in Ectopic Pregnancies
title_short Evaluation of Oxidative Stress in Ectopic Pregnancies
title_sort evaluation of oxidative stress in ectopic pregnancies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972882/
https://www.ncbi.nlm.nih.gov/pubmed/35315421
http://dx.doi.org/10.23750/abm.v93i1.11097
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