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KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia

GABAergic system disinhibition played an important role in the pathogenesis of remifentanil-induced hyperalgesia (RIH). K(+)-Cl(-)-cotransporter-2 (KCC2) has the potential to enhance the strength of GABAergic signaling function. However, few reports have focused on the additive analgesic effect of K...

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Detalles Bibliográficos
Autores principales:	Gao, Yuan, Zhan, Wenqiang, Jin, Yushi, Chen, Xiaodan, Cai, Jinxia, Zhou, Xiaotian, Huang, Xinyi, Zhao, Qimin, Wang, Weijian, Sun, Jiehao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972932/ https://www.ncbi.nlm.nih.gov/pubmed/35352582 http://dx.doi.org/10.1177/17448069221082880

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