Cargando…

Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage

Macrophages, mainly divided into M1 pro-inflammatory and M2 anti-inflammatory types, play a key role in the transition from inflammation to repair after trauma. In chronic inflammation, such as diabetes and complex bone injury, or the process of certain inflammatory specific emergencies, the ratio o...

Descripción completa

Detalles Bibliográficos
Autores principales: Song, Nan, Pan, Kaifeng, Chen, Lei, Jin, Keke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972998/
https://www.ncbi.nlm.nih.gov/pubmed/35370988
http://dx.doi.org/10.3389/fendo.2022.868893
_version_ 1784679968350928896
author Song, Nan
Pan, Kaifeng
Chen, Lei
Jin, Keke
author_facet Song, Nan
Pan, Kaifeng
Chen, Lei
Jin, Keke
author_sort Song, Nan
collection PubMed
description Macrophages, mainly divided into M1 pro-inflammatory and M2 anti-inflammatory types, play a key role in the transition from inflammation to repair after trauma. In chronic inflammation, such as diabetes and complex bone injury, or the process of certain inflammatory specific emergencies, the ratio of M1/M2 cell populations is imbalanced so that M1-macrophages cannot be converted into M2 macrophages in time, resulting in delayed trauma repair. Early and timely transformation of macrophages from the pro-inflammatory M1-type into the pro-reparative M2-type is an effective strategy to guide trauma repair and establish the original homeostasis. We prepared purified nano-platelet vesicles (NPVs) and assessed their effects on macrophage phenotype switching through transcriptome analysis. The results elucidate that NPVs promote pathways related to angiogenesis, collagen synthesis, cell adhesion, and migration in macrophages, and we speculate that these advantages may promote healing in traumatic diseases.
format Online
Article
Text
id pubmed-8972998
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89729982022-04-02 Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage Song, Nan Pan, Kaifeng Chen, Lei Jin, Keke Front Endocrinol (Lausanne) Endocrinology Macrophages, mainly divided into M1 pro-inflammatory and M2 anti-inflammatory types, play a key role in the transition from inflammation to repair after trauma. In chronic inflammation, such as diabetes and complex bone injury, or the process of certain inflammatory specific emergencies, the ratio of M1/M2 cell populations is imbalanced so that M1-macrophages cannot be converted into M2 macrophages in time, resulting in delayed trauma repair. Early and timely transformation of macrophages from the pro-inflammatory M1-type into the pro-reparative M2-type is an effective strategy to guide trauma repair and establish the original homeostasis. We prepared purified nano-platelet vesicles (NPVs) and assessed their effects on macrophage phenotype switching through transcriptome analysis. The results elucidate that NPVs promote pathways related to angiogenesis, collagen synthesis, cell adhesion, and migration in macrophages, and we speculate that these advantages may promote healing in traumatic diseases. Frontiers Media S.A. 2022-03-18 /pmc/articles/PMC8972998/ /pubmed/35370988 http://dx.doi.org/10.3389/fendo.2022.868893 Text en Copyright © 2022 Song, Pan, Chen and Jin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Song, Nan
Pan, Kaifeng
Chen, Lei
Jin, Keke
Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title_full Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title_fullStr Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title_full_unstemmed Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title_short Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage
title_sort platelet derived vesicles enhance the tgf-beta signaling pathway of m1 macrophage
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8972998/
https://www.ncbi.nlm.nih.gov/pubmed/35370988
http://dx.doi.org/10.3389/fendo.2022.868893
work_keys_str_mv AT songnan plateletderivedvesiclesenhancethetgfbetasignalingpathwayofm1macrophage
AT pankaifeng plateletderivedvesiclesenhancethetgfbetasignalingpathwayofm1macrophage
AT chenlei plateletderivedvesiclesenhancethetgfbetasignalingpathwayofm1macrophage
AT jinkeke plateletderivedvesiclesenhancethetgfbetasignalingpathwayofm1macrophage