Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols

Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding pro...

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Detalles Bibliográficos
Autor principal: Musa, Musa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973272/
https://www.ncbi.nlm.nih.gov/pubmed/35191611
http://dx.doi.org/10.1002/open.202100251
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author Musa, Musa M.
author_facet Musa, Musa M.
author_sort Musa, Musa M.
collection PubMed
description Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti‐Prelog stereopreference. Both wild‐type and engineered ADHs that exhibit anti‐Prelog stereopreference are highlighted.
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spelling pubmed-89732722022-04-05 Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols Musa, Musa M. ChemistryOpen Reviews Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti‐Prelog stereopreference. Both wild‐type and engineered ADHs that exhibit anti‐Prelog stereopreference are highlighted. John Wiley and Sons Inc. 2022-02-22 /pmc/articles/PMC8973272/ /pubmed/35191611 http://dx.doi.org/10.1002/open.202100251 Text en © 2022 The Authors. Published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Musa, Musa M.
Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title_full Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title_fullStr Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title_full_unstemmed Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title_short Alcohol Dehydrogenases with anti‐Prelog Stereopreference in Synthesis of Enantiopure Alcohols
title_sort alcohol dehydrogenases with anti‐prelog stereopreference in synthesis of enantiopure alcohols
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973272/
https://www.ncbi.nlm.nih.gov/pubmed/35191611
http://dx.doi.org/10.1002/open.202100251
work_keys_str_mv AT musamusam alcoholdehydrogenaseswithantiprelogstereopreferenceinsynthesisofenantiopurealcohols

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