Cargando…

Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria

Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform. Indirubin and cantharidin increased mitochondri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heo, Keunjung, Basu, Himanish, Gutnick, Amos, Wei, Wei, Shlevkov, Evgeny, Schwarz, Thomas L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973303/ https://www.ncbi.nlm.nih.gov/pubmed/35370563 http://dx.doi.org/10.3389/fncel.2022.852245

Ejemplares similares

Beyond the Dopamine Receptor: Regulation and Roles of Serine/Threonine Protein Phosphatases
por: Walaas, Sven Ivar, et al.
Publicado: (2011)

A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
por: Shlevkov, Evgeny, et al.
Publicado: (2019)

The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria.
por: Gutnick, Amos, et al.
Publicado: (2019)

The serine-threonine protein phosphatases that regulate the thiazide-sensitive NaCl cotransporter
por: Carbajal-Contreras, Héctor, et al.
Publicado: (2023)

Lead Dysregulates Serine/Threonine Protein Phosphatases in Human Neurons
por: Rahman, Abdur, et al.
Publicado: (2010)

Regulation of Hemolysin Expression and Virulence of Staphylococcus aureus by a Serine/Threonine Kinase and Phosphatase
por: Burnside, Kellie, et al.
Publicado: (2010)

Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division
por: Iswahyudi, et al.
Publicado: (2019)

Serine/Threonine Protein Phosphatases 1 and 2A in Lung Endothelial Barrier Regulation
por: Patil, Rahul S., et al.
Publicado: (2023)

Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma
por: Shen, Y, et al.
Publicado: (2011)

Dysregulation of the serine/threonine phosphatase PP2A contributes to autoimmunity
por: Crispín, JC
Publicado: (2012)

A serine/threonine phosphatase, PP2A, controls autoimmunity
por: Tsokos, George C
Publicado: (2014)

Protein Serine/Threonine Phosphatase Type 2C of Leishmania mexicana
por: Escalona-Montaño, Alma Reyna, et al.
Publicado: (2021)

Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro
por: Wasserman, Jason S., et al.
Publicado: (2023)

Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens
por: Wright, David P, et al.
Publicado: (2015)

The serine/threonine kinase Stk and the phosphatase Stp regulate cell wall synthesis in Staphylococcus aureus
por: Jarick, Marcel, et al.
Publicado: (2018)

The role of serine/threonine phosphatases in human development: Evidence from congenital disorders
por: Vaneynde, Pieter, et al.
Publicado: (2022)

Serine / threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
por: Dean, David A, et al.
Publicado: (2001)

Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells
por: Chen, Ming, et al.
Publicado: (2017)

Age-Dependent Protein Expression of Serine/Threonine Phosphatases and Their Inhibitors in the Human Cardiac Atrium
por: Gergs, Ulrich, et al.
Publicado: (2019)

Role of serine/threonine protein phosphatase PrpN in the life cycle of Bacillus anthracis
por: Gangwal, Aakriti, et al.
Publicado: (2022)

Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
por: Miller, Peter G., et al.
Publicado: (2022)

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets
por: Makhoul, Stephanie, et al.
Publicado: (2020)

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond
por: Lee, Kyu-Sun, et al.
Publicado: (2014)

A serine/threonine phosphatase encoded by MG_207 of Mycoplasma genitalium is critical for its virulence
por: Martinez, Mario A, et al.
Publicado: (2013)

Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans
por: Chen, Emily, et al.
Publicado: (2016)

A serine/threonine phosphatase 1 of Streptococcus suis type 2 is an important virulence factor
por: Fang, Lihua, et al.
Publicado: (2017)

Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System
por: Liang, Qin-Li, et al.
Publicado: (2022)

Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-, and threonine-rich sequence (PEST)
por: Zheng, Yanhua, et al.
Publicado: (2013)

A Pseudorabies Virus Serine/Threonine Kinase, US3, Promotes Retrograde Transport in Axons via Akt/mToRC1
por: Esteves, Andrew D., et al.
Publicado: (2022)

FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply
por: Basu, Himanish, et al.
Publicado: (2021)

Activation of Protein Serine/Threonine Phosphatase PP2Cα Efficiently Prevents Liver Fibrosis
por: Wang, Lirui, et al.
Publicado: (2010)

Catalytic activity of a novel serine/threonine protein phosphatase PP5 from Leishmania major
por: Norris-Mullins, Brianna, et al.
Publicado: (2014)

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments
por: Janczarek, Monika, et al.
Publicado: (2018)

Serine/Threonine Phosphatases in LTP: Two B or Not to Be the Protein Synthesis Blocker-Induced Impairment of Early Phase
por: Maltsev, Alexander V., et al.
Publicado: (2021)

Development of a novel pharmacophore model to screen specific inhibitors for the serine-threonine protein phosphatase calcineurin
por: Mukherjee, Abhisek, et al.
Publicado: (2022)

Resistance to serine in Bacillus subtilis: identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism
por: Klewing, Anika, et al.
Publicado: (2020)

The Role of Microtubule Associated Serine/Threonine Kinase 3 Variants in Neurodevelopmental Diseases: Genotype-Phenotype Association
por: Shu, Li, et al.
Publicado: (2022)

Deleterious Variation in BR Serine/Threonine Kinase 2 Classified a Subtype of Autism
por: Deng, Jingxin, et al.
Publicado: (2022)

The triglyceride catabolism regulated by a serine/threonine protein phosphatase, Smek1, is required for development and plant infection in Magnaporthe oryzae
por: Huang, Zhicheng, et al.
Publicado: (2023)

Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5
por: Park, Soo-Yeon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_vgpfjs8vr1b6s404v9q9u6s40t