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IL-6/IFN-γ double knockdown CAR-T cells reduce the release of multiple cytokines from PBMCs in vitro

CD19-targeted chimeric antigen receptor T (anti-CD19 CAR-T) cells have shown good therapeutic results in the treatment of CD19 + B cell acute lymphocytic leukemia and lymphoma. However, severe side reactions and cytotoxicity are great challenges in the application of anti-CD19 CAR-T cell therapy. Cy...

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Detalles Bibliográficos
Autores principales:	Zhang, Huihui, Lv, Xiaofei, Kong, Qunfang, Tan, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Immunotherapy – Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973323/ https://www.ncbi.nlm.nih.gov/pubmed/35049413 http://dx.doi.org/10.1080/21645515.2021.2016005

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